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IL8 — UTP6
Text-mined interactions from Literome
Idzko et al., Br J Pharmacol 2003
:
Release of
IL-8 was
triggered by UDP, ATP, alpha, beta-meATP and BzATP, but not by
UTP or ADP
Marcet et al., J Cell Physiol 2007
:
Furthermore,
UTP had no effect on interleukin-(IL)-8 release and
reduced the release of both CCL20 and
IL-8 induced by TNF-alpha and LPS
Relvas et al., Invest Ophthalmol Vis Sci 2009
:
This investigation focused on whether extracellular nucleotides could contribute to this activation, and the
effects of ATPgammaS,
UTP , and UDP on the production of
IL-8 by RPE cells was studied in relation to their expression of functional P2Y receptors ... Stimulation of ARPE-19 cells with ATPgammaS,
UTP , and UDP
induced IL-8 gene transcription and protein secretion ... TNFalpha induction of
IL-8 secretion was also
increased by ATPgammaS,
UTP , and UDP ... ATPgammaS,
UTP , and UDP
stimulate both basal and TNFalpha induced
IL-8 secretion in RPE cells through an ERK 1/2 dependent pathway