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PI3 — STAT1

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 2001 : We show that phosphatidylinositol 3-kinase (PI3K) and its effector kinase Akt play an important role in the serine phosphorylation of STAT1 and in the activation of gene expression in response to interferon-gamma (IFN gamma)
Nguyen et al., J Interferon Cytokine Res 2003 : Analyses of mutant I1A cells, which lack the IL-1 receptor associated kinase (IRAK), and of I1A cells reconstituted with deletion mutants of IRAK show that the IL-1 mediated phosphorylation of Stat1 on serine requires the IRAK protein but not its kinase activity and does not involve phosphatidylinositol-3'-kinase (PI3K) or the mitogen activated protein ( MAP ) kinases p38 or ERK
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models