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MAPK14 — MYL2
Text-mined interactions from Literome
Kim et al., Matrix Biol 2010
(MAP Kinase Signaling System) :
Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and
MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and
myosin II motor activity to
induce migration of Tr cells
Fischer et al., Am J Physiol Gastrointest Liver Physiol 2013
:
At the signaling level, adalimumab prevented increased phosphorylation of
myosin light chain as well as
activation of p38
MAPK and NF-?B accompanying the decline in TEER in both model systems