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BAX — EGFR
Text-mined interactions from Literome
Wang et al., Zhonghua Zhong Liu Za Zhi 2003
(Glioblastoma) :
Bcl-2 and
Bax , being nuclear matrix associated proteins, are probably
involved in the
EGFR-cDNA induced malignant conversion of glioblastoma cells by introducing EGFR cDNA into the tumor cells
Bernal et al., Gastroenterology 2006
:
Epidermal growth factor receptor signaling
regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice
Ge et al., Biol Reprod 2009
:
On the other hand, inhibition of
EGFR , Ca ( 2+ ) /PKC, or NFKB1 abolished the EGF stimulated increase in the expression of cyclins CCND1 and CCNE1, cyclin dependent kinase 6 (CDK6), CDK2, and BCL2, and
restored the EGF induced inhibition of
BAX expression and caspase 3/9 activity, indicating that EGFR, PKC, and NFKB1 signaling cascades were involved in EGF stimulated DNA synthesis and antiapoptosis action
Yan et al., Gastroenterology 2009
(Disease Models, Animal...) :
Furthermore, H pylori induced
EGFR phosphorylation
stimulated phosphotidylinositol-3'-kinase dependent activation of the antiapoptotic factor Akt, increased expression of the antiapoptotic factor Bcl-2, and decreased expression of the proapoptotic factor
Bax