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EGFR — PI3
Text-mined interactions from Literome
Wu et al., Oncogene 2000
(Brain Neoplasms...) :
Inhibition of
EGFR mediated
phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins ( SIRPs )
Pianetti et al., Oncogene 2001
(Breast Neoplasms...) :
Overexpression of Her-2/neu and
EGFR-4 in Ba/F3 cells
led to constitutive
PI3- and Akt kinase activities, and induction of classical NF-kappaB ( p50/p65 )
Auge et al., Arterioscler Thromb Vasc Biol 2002
(MAP Kinase Signaling System) :
Coimmunoprecipitation experiments and the use of inhibitors and dominant negative mutant showed that oxLDL induced
PI-3K activation is
dependent on
EGFR
Hassan et al., Regul Pept 2004
(Prostatic Neoplasms) :
The effects of NT on
EGFR/ERK/Akt activation and DNA synthesis were
attenuated by PLC-inhibitor ( U73122 ), PKC-inhibitors ( bisindolylmaleimide, staurosporine, rottlerin ), MEK inhibitor ( U0126 ) and
PI3 kinase inhibitors ( wortmannin, LY 294002 )
Cappuzzo et al., J Natl Cancer Inst 2004
(Carcinoma, Non-Small-Cell Lung...) :
Phosphatidylinositol 3'-kinase (PI3K)/Akt and Ras/Raf/mitogen activated protein kinase ( MAPK ), the two main EGFR signaling pathways,
mediate EGFR effects on proliferation and survival
Le Page et al., Prostate 2005
(Prostatic Neoplasms) :
Independent
role of
phosphoinositol-3-kinase (PI3K) and casein kinase II ( CK-2 ) in
EGFR and Her-2 mediated constitutive NF-kappaB activation in prostate cancer cells
Ihle et al., Mol Cancer Ther 2005
(Carcinoma, Non-Small-Cell Lung...) :
Recent work shows that
phosphatidylinositol-3-kinase (PI3-K) is coupled to the EGFR only in NSCLC cell lines expressing ErbB-3 and that
EGFR inhibitors do not
inhibit PI3-K signaling in these cells
Nie et al., Mech Dev 2007
:
In this study, we show that
phosphatidylinositol-3 kinase (PI3K) and Erk mitogen activated protein kinase ( MAPK )
mediate ErbB signaling to regulate gastrulation
Rodland et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
This enhancement of
EGFR signaling was
independent of both receptor phosphorylation and
PI-3-kinase activity, suggestive of a novel mechanism
Yin et al., Invest Ophthalmol Vis Sci 2010
:
Heparin binding EGF-like growth factor ( HB-EGF ) shedding was assessed by measuring the release of alkaline phosphatase ( AP ) in a stable HCEC line expressing HB-EGF-AP.
Activation of
EGFR ,
phosphoinositide 3-kinase (PI3K) , and extracellular signal regulated kinases 1/2 ( ERK1/2 ) was determined by Western blot analysis
Su et al., Clin Exp Pharmacol Physiol 2010
:
The results indicated that CTX III suppresses phosphorylation of
EGFR and
activation of
phosphatidylinositol 3-kinase (PI3-K)/Akt and Janus tyrosine kinase (JAK) 2/signal transducer and activator of transcription ( STAT ) 3, all of which are downstream molecules in the EGFR signalling pathway
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012
:
In conclusion, PAR(2) activation drives COX-2 expression in Caco-2 cells via metalloproteinase dependent
EGFR transactivation and
activation of Src, Rho, and
PI3 kinase signaling
Tabara et al., PloS one 2012
(Lung Neoplasms) :
However, constitutive
activation of
EGFR downstream signaling,
PI3K/Akt , was observed even after loss of the mutated EGFR gene in all resistant cell lines even in the presence of the drug
Zhang et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2011
:
These findings suggest that exogenous 14,15-EET has potent inhibitory effect on proliferation, and could induce apoptosis in Tca-8113 cell, and these changes are related to the expression of PPAR?, the
activation of
EGFR , ERK, and
PI3 kinase/AKT proteins
Kim et al., J Neurochem 2013
(MAP Kinase Signaling System) :
Stimulation of the
ErbB receptors by NRG1ß
activated the
phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK )
Li et al., Cancer Biother Radiopharm 2013
(Adenocarcinoma...) :
Recent evidence indicates that both the
phosphatidylinositol 3-kinase (PI3K)/AKT and the MEK/ERK pathways are strictly
regulated by
epidermal growth factor receptor in non-small cell lung cancer ( NSCLC ) that responds to Gefitinib
Weiss et al., Journal of gastrointestinal oncology 2013
:
Phosphatidylinositol-3-kinase (PI3K) activation
involves the
epidermal growth factor receptor (EGFR) and plays an important role in cell survival signaling in pancreaticobiliary cancer