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APC — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jaiswal et al., J Biol Chem 2001
(Colonic Neoplasms) :
p53 dependent transcriptional regulation of the
APC promoter in colon cancer cells treated with DNA alkylating agents ... In the present study, we examined the
role of
p53 in the transcriptional regulation of
APC promoter and characterized two p53 binding sites on the cloned APC promoter ( pAPCP )
Guo et al., Eur J Neurosci 2009
(Anoxia...) :
In neurons and BECs,
3K3A-APC blocked caspase-9 and -3 activation and induction of
p53 , and decreased the Bax/Bcl-2 pro-apoptotic ratio
Gorbacheva et al., Neurochem Int 2013
:
To elucidate the NF-?B dependent and -independent mechanisms in the APC mediated cell survival, we analyzed in cortical and hippocampal neurons the
effects of helenalin, a specific inhibitor of NF-?B activity, and
APC on neuronal cell death and on the level of nuclear AIF,
p53 , caspase-3 and the apoptotic index ( Bax/Bcl-2 ratio )
Narayan et al., J Biol Chem 1997
:
A necessary
role for
p53 in
APC gene regulation is supported by the failure of MNNG to induce APC expression in cell lines either expressing very low levels of p53 ( HeLa cells ) or no p53 ( K562 erythroleukemia cells ) ... A direct causal
role for
p53 in
APC gene regulation was further evaluated by transfecting the wild-type p53 gene into K562 cells and observing a 5-fold increase in the APC gene expression
Jaiswal et al., Int J Oncol 1998
:
In the present study, we show that treatment of wild-type ( p53+/+ ) mouse embryonic fibroblast (MEF) cells with a DNA alkylating agent, N-methyl-N'-nitro-N-nitro-soguanidine ( MNNG ), resulted in increased levels of adenomatous polyposis coli (APC) mRNA compared to p53 gene knocked out (p53-/-) MEF cells, indicating that
p53 is
required for
APC expression after alkylation damage ... By using HCT-116 colon cancer cells ( containing wild-type p53 gene ) or p53-/- MEF cells transfected with a pCMV-p53 overexpression plasmid [p53-/- ( CMV-p53 ) ], we show that
p53 is a labile factor for APC gene expression, and that pretreating HCT-116 cells with a protein synthesis inhibitor, cycloheximide ( CHX ),
inhibited MNNG induced
APC mRNA levels by inhibiting p53 protein synthesis ... To examine whether
p53 regulates
APC gene expression at the transcriptional level, we treated HCT-116 or p53-/- ( CMV-p53 ) MEF cells with 5,6-dichloro-1-beta-D-ribofuranosylbenzamidazole ( DRB ; a transcriptional inhibitor ), before the MNNG treatment ... Although treatment of cells with DRB resulted in increased p53 protein levels, that the APC mRNA levels were decreased suggests that
p53 may
enhance APC gene expression upstream of the transcriptional machinery where DRB interacts