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PLD4 — RHO

Text-mined interactions from Literome

Schmidt et al., J Biol Chem 1999 : Overexpression of Rho-kinase and constitutively active Rho-kinase ( Rho-kinase-CAT ) but not of kinase-deficient Rho-kinase-CAT markedly increased m3 mAChR mediated but not protein kinase C-mediated PLD stimulation, similar to overexpression of RhoA ... We conclude that Rho-kinase is involved in Rho dependent PLD stimulation by the G protein coupled m3 mAChR in HEK-293 cells
Meacci et al., J Biol Chem 1999 (Adenocarcinoma) : It also had no effect on Rho stimulated PLD activity, indicating that RhoA action did not involve a BFA-sensitive pathway
Fahimi-Vahid et al., J Mol Cell Cardiol 2002 : We conclude that, in contrast to ET ( A ) R-PLD coupling, PAR1 induced cardiomyocyte PLD stimulation is PKC independent and mediated by G ( 12 ) -type G proteins and ARF GTPases, while Rho and tyrosine kinases regulate PLD stimulation by either receptor, apparently by controlling the cellular level of PIP ( 2 ), a common regulator of PLD activity
Walker et al., J Biol Chem 2002 : Specificity of Rho insert mediated activation of phospholipase D1
Gosau et al., Naunyn Schmiedebergs Arch Pharmacol 2002 : ARF and Rho GTPases as well as protein tyrosine kinases contribute to PLD stimulation in NRCM, most likely by regulating the supply of PIP ( 2 )
Huang et al., Am J Physiol Cell Physiol 2004 : These findings demonstrate that the CaR couples to Galpha12/13 to regulate PLD via a Rho dependent mechanism and does so independently of Galphai and Galphaq
Mansfield et al., Blood 2004 : In streptolysin O-permeabilized PMNs, PLD was directly activated by guanosine 5'- [ gamma-thio ] triphosphate ( GTP gamma S ) stimulation of adenosine diphosphate ( ADP ) -ribosylation factor ( ARF ) and Rho , stimulating release of lactoferrin from specific granules of permeabilized PMNs ; PLD activation and degranulation were inhibited by C2-ceramide but not dihydro-C2-ceramide
Ziembicki et al., American journal of physiology. Renal physiology 2005 : Mechanical force activated phospholipase D is mediated by Galpha12/13-Rho and calmodulin dependent kinase in renal epithelial cells
Huang et al., Blood 2012 : PLD activation and VWF secretion induced by Stx1B were abolished on protein kinase Ca ( PKCa ) inhibition or gene silencing but were only moderately reduced by Rho or Rho kinase inhibitors ... Conversely, PLD activation and VWF exocytosis induced by Stx2B were reduced by Rho/Rho kinase inhibitors and dominant negative RhoA, whereas attenuation of PKCa did not affect either process
Esteve et al., Oncogene 1995 : In the present study, we provide evidence that overexpression of the Aplysia Rho protein in NIH 3T3 cells induces the generation of phosphatidylcholine ( PC ) -derived second messengers as a result of activation of a PC-specific phospholipase D ( PC-PLD ) as previously reported for ras transformed cells
Malcolm et al., J Biol Chem 1996 : Evidence for Rho mediated agonist stimulation of phospholipase D in rat1 fibroblasts
Martin et al., J Biol Chem 1996 : Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho ... Arf stimulated but not Rho stimulated PLD activity was increased by the inclusion of Mg2+ and ATP ... Therefore, although recombinant Arf and Rho can activate PLD and PIP kinase in HL60 cells, it is the endogenous Arf but not Rho that regulates PLD, and thus a role for Rho in the physiological regulation of PLD in HL60 cells is unlikely
Brindley et al., Biochem Cell Biol 1996 (Insulin Resistance...) : By contrast, ceramides inhibit the activation of phospholipase D by decreasing its interaction with the G-proteins, ARF and Rho , which are necessary for its activation
Hess et al., J Biol Chem 1997 : Role of Rho family proteins in phospholipase D activation by growth factors
Karnam et al., J Biol Chem 1997 : Because Rho and ADP ribosylation factor ( ARF ) activate PC-PLD , we questioned whether these small G-proteins are regulated by insulin and PI 3-kinase ... Our findings suggest that : ( a ) insulin translocates Rho by a PI 3-kinase dependent mechanism, but another factor is responsible for GTP loading of Rho ; ( b ) both Rho and ARF may contribute to PC-PLD activation during insulin action ; and ( c ) Rho may be required for insulin stimulation of glucose transport
Kato et al., Prostaglandins 1997 : To examine the role of Rho family proteins in prostaglandin F2 alpha ( PGF2 alpha ) -mediated phospholipase D ( PLD ) activation of osteoblast-like cell line MC3T3-E1 cells, we used Toxin-B from Clostridium difficile, which inhibits Rho family proteins by monoglucosylation
van Dijk et al., Curr Biol 1998 : Exogenous phospholipase D generates lysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways
Fensome et al., J Biol Chem 1998 : ADP-ribosylation factor and Rho proteins mediate fMLP dependent activation of phospholipase D in human neutrophils ... C3 toxin, which inactivates Rho proteins, reduces the ARF reconstituted PLD activity, illustrating that although Rho alone does not stimulate PLD activity, it synergizes with ARF
Guillemain et al., Biochim Biophys Acta 1998 : In the present study, we examined the role of Rho proteins in PLD activation in differentiated HL-60 cells using C3 exoenzyme from Clostridium botulinum, which ADP-ribosylates and inactivates Rho proteins