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CD40 — CSF2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
von Leoprechting et al., Cancer Res 1999
(Melanoma) :
CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein
up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a, and granulocyte macrophage
colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Wei et al., J Neuroimmunol 1999
:
IL-4, transforming growth factor-beta1, and nerve growth factor (NGF) repress
GM-CSF induced B7-2 and
CD40 , but not B7-1
Li et al., Scand J Immunol 2000
:
Lipopolysaccharide (LPS) treatment
induced the upregulation of
CD40 , CD80, CD86 and the T-cell stimulatory capacity in IL-4-DCs and, to a lesser extent, in the IL-7-DCs whereas
GM-CSF-DCs responded very poorly to such treatment
Tada et al., Eur J Immunol 2001
:
More importantly, it was found that in contrast to TGF-beta, granulocyte/macrophage
colony stimulating factor ( GM-CSF ) strikingly
inhibits IL-12 production of
anti-CD40/IFN -- stimulated LC and that the level of LC IL-12 production is determined by the relative amounts of TGF-beta1 and GM-CSF
Kitagawa et al., J Rheumatol 2001
(Arthritis, Rheumatoid) :
We examined the
effects of IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and granulocyte-macrophage
colony stimulating factor ( GM-CSF ) on
CD40 expression on CD68+ synovial macrophage-lineage cells ( SMC )
Hornell et al., J Immunol 2003
:
GM-CSF also
increases expression of the costimulatory molecules CD86 and
CD40 , but not the differentiation marker CD1a or CD16
Cao et al., Oral Oncol 2005
(Head and Neck Neoplasms...) :
CD40 ligation specifically
increased the secretion of IL-8, VEGF and PGE ( 2 ) but not IL-6, IL-10, FasL,
GM-CSF , or TGFalpha
Vital et al., Biosci Rep 2004
(Dermatitis, Contact) :
The epidermal cytokine granulocyte-macrophage
colony stimulating factor ( GM-CSF ), also used in the experiments, slightly
increased the expression of both
CD40 and IL-12R and when tested together with the sensitizers the effect was partially additive
McLellan et al., Eur J Immunol 1996
:
However,
CD40 was rapidly up-regulated by culture, and its expression was further
enhanced by interleukin (IL)-1 alpha, IL-1 beta, IL-3, tumor necrosis factor-alpha and
granulocyte/macrophage-colony stimulating factor
Iwasaki et al., Clin Exp Immunol 1998
:
CD40 also
augmented tumour necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage
colony stimulating factor ( GM-CSF ) expression but resulted in decreased IL-10 expression
Möttönen et al., Br J Rheumatol 1998
(Arthritis, Rheumatoid) :
IL-4 +
GM-CSF , a combination of cytokines known to induce differentiation of dendritic cells,
increased the expression of
CD40 , CD80 and CD86, and decreased the expression of CD14 on SF macrophages