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EGFR — PLCG1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (directlyIncreases, PLCG1 Activity)
  Evidence: 1689310;1708307;12601080;15144186;17081983
• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (directlyIncreases, PLCG1 Activity)
  Evidence: 96108162;1689310;1708307
• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (directlyIncreases, PLCG1 Activity)
  Evidence: 1689310;7991458;12601080
• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (directlyIncreases, PLCG1 Activity)
  Evidence: In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways.
• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (directlyIncreases, PLCG1 Activity)
  Evidence: Despite extensive overlap in the molecules recruited to the active receptors, there is some preferential modulation of signalling pathways. Tumour cells that express EGFR with kinase-domain mutations preferentially activate the pro-survival PI3K?AKT and signal transducer and activator of transcription (STAT) pathways67. Although EGFR has no consensus sequence for the p85 adaptor subunit of PI3K, it couples to this pathway through GAB1, which binds growth-factorreceptor- bound protein 2 (GRB2).
• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (directlyIncreases, PLCG1 Activity)
  Evidence: 1689310;1708307;8657103;12601080;15144186;15592455;16038803
• OpenBEL Selventa BEL large corpus: PLCG1 → EGFR (increases, PLCG1 Activity)
  Evidence: This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth
• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → PLC-gamma (PLCG1) (modification, activates)
• KEGG Pathways in cancer: EGFR → PLCG1/PLCG2 (protein-protein, activation)
• KEGG Glioma: EGFR → PLCG1/PLCG2 (protein-protein, activation)
• KEGG Glioma: EGFR → PLCG1/PLCG2 (protein-protein, activation)
• KEGG ErbB signaling pathway: Complex of EGFR → PLCG1/PLCG2 (protein-protein, activation)
• KEGG ErbB signaling pathway: EGFR → PLCG1/PLCG2 (protein-protein, activation)
• KEGG Non-small cell lung cancer: PLCG1/PLCG2 → EGFR (protein-protein, compound)
• KEGG Non-small cell lung cancer: PLCG1/PLCG2 → EGFR (protein-protein, compound)
• KEGG Non-small cell lung cancer: EGFR → PLCG1/PLCG2 (protein-protein, activation)
• KEGG Calcium signaling pathway: EGFR/ERBB2/ERBB3/ERBB4/PDGFRA/PDGFRB → PLCG1/PLCG2 (protein-protein, activation)
• Reactome Reaction: EGFR → PLCG1 (reaction) Chattopadhyay et al., J Biol Chem 1999*, Carpenter et al., Exp Cell Res 1999, Sordella et al., Science 2004, Greulich et al., PLoS Med 2005, Fazioli et al., Mol Cell Biol 1991*, Wahl et al., J Biol Chem 1990, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Xu et al., Br J Cancer 2007, Margolis et al., Mol Cell Biol 1990*, Meisenhelder et al., Cell 1989, Cohen et al., J Biol Chem 1996*
• Reactome Reaction: EGFR → PLCG1 (indirect_complex) Chattopadhyay et al., J Biol Chem 1999*, Sordella et al., Science 2004, Greulich et al., PLoS Med 2005, Fazioli et al., Mol Cell Biol 1991*, Wahl et al., J Biol Chem 1990, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Xu et al., Br J Cancer 2007, Margolis et al., Mol Cell Biol 1990*, Meisenhelder et al., Cell 1989, Cohen et al., J Biol Chem 1996*
• WikiPathways ErbB Signaling Pathway: EGFR → PLCG1 (activation)
• WikiPathways ErbB Signaling Pathway: EGFR → PLCG1 (activation)
• WikiPathways Signaling Pathways in Glioblastoma: IGF1R/ERBB3/FGFR1/PDGFRA/PDGFRB/ERBB2/EGFR/FGFR2/MET → PLCG1/PLCG2 (mim-stimulation)
• WikiPathways Association Between Physico-Chemical Features and Toxicity Associated Pathways: EGFR → PLCG1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PLCG1 — EGFR Anderson et al., Science 1990*, Margolis et al., EMBO J 1990*
• IRef Bind_translation Interaction: PLCG1 — EGFR (affinity chromatography technology) Anderson et al., Science 1990*, Margolis et al., EMBO J 1990*
• IRef Bind_translation Interaction: PLCG1 — EGFR (affinity chromatography technology) Anderson et al., Science 1990*
• IRef Bind_translation Interaction: PLCG1 — EGFR (experimental interaction detection) Anderson et al., Science 1990*, Margolis et al., EMBO J 1990*
• IRef Biogrid Interaction: EGFR — PLCG1 (physical association, affinity chromatography technology) Crovello et al., J Biol Chem 1998
• IRef Biogrid Interaction: EGFR — PLCG1 (physical association, affinity chromatography technology) Choi et al., Mol Cells 2003*
• IRef Biogrid Interaction: EGFR — PLCG1 (direct interaction, unspecified method) Jones et al., Nature 2006
• IRef Biogrid Interaction: EGFR — PLCG1 (physical association, affinity chromatography technology) Tvorogov et al., Exp Cell Res 2002*
• IRef Biogrid Interaction: EGFR — PLCG1 (physical association, affinity chromatography technology) Bedrin et al., J Cell Physiol 1997*
• IRef Hprd Interaction: EGFR — PLCG1 (in vivo) Hinsby et al., Mol Cell Proteomics 2003*, Brill et al., Anal Chem 2004, Kim et al., J Biol Chem 1990*, Liao et al., Biochem Biophys Res Commun 1993*, Law et al., Mol Cell Biol 1996, Sidorenko et al., Immunity 1996*, Bedrin et al., J Cell Physiol 1997*
• IRef Hprd Interaction: EGFR — PLCG1 (in vitro) Hinsby et al., Mol Cell Proteomics 2003*, Brill et al., Anal Chem 2004, Kim et al., J Biol Chem 1990*, Liao et al., Biochem Biophys Res Commun 1993*, Law et al., Mol Cell Biol 1996, Sidorenko et al., Immunity 1996*, Bedrin et al., J Cell Physiol 1997*
• IRef Intact Interaction: EGFR — PLCG1 (direct interaction, protein array) Jones et al., Nature 2006
• IRef Intact Interaction: EGFR — PLCG1 (physical association, coimmunoprecipitation) Kwon et al., J Cell Biol 2003*
• IRef Intact Interaction: EGFR — PLCG1 (association, pull down) Milarski et al., J Biol Chem 1993*
• IRef Intact Interaction: EGFR — PLCG1 (association, cross-linking study) Gergel et al., Biochemistry 1994*
• IRef Intact Interaction: EGFR — PLCG1 (physical association, pull down) Emlet et al., J Biol Chem 1997*
• IRef Intact Interaction: EGFR — PLCG1 (physical association, far western blotting) Emlet et al., J Biol Chem 1997*
• IRef Ophid Interaction: EGFR — PLCG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: EGFR — PLCG1 (aggregation, confirmational text mining) Jones et al., Nature 2006

Text-mined interactions from Literome

Zhang et al., Biochem Biophys Res Commun 1999 (Calcium Signaling) : Activation of PLC-gamma1 by EGFR requires the EGFR to bind to PLC-gamma1 after its translocation from cytosol to cytoskeleton
Telting et al., Biochim Biophys Acta 1999 (Calcium Signaling) : The EGFR specifically activates phospholipase C-gamma1 ( PLC-gamma1 )
Bae et al., FEBS Lett 2001 : Cleavage of EGFR by caspase-3 significantly impaired the tyrosine phosphorylation of PLC-gamma1 in vitro
Zhang et al., Biochem Pharmacol 2001 : In hepatocytes, activation of PLC-(gamma1) by EGFR requires involvement of a pertussis toxin-sensitive inhibitory guanine nucleotide binding regulatory protein ( G ( alphai ) ) as an intermediate
David-Dufilho et al., J Biol Chem 2005 (Atherosclerosis...) : Complete epidermal growth factor receptor inhibition only partly reduced the activation of phospholipase Cgamma1 and NOS3
Wang et al., Mol Biol Cell 2006 : EGFR activates PLC-gamma1 directly and activates Akt indirectly through phosphatidylinositol 3-kinase (PI3K)
Zhan et al., Cancer Res 2006 (Breast Neoplasms...) : The ability of heterodimers to induce invasion required the ErbB1 kinase activity and required activation of PI3K, Ras/mitogen activated protein kinase, and phospholipase Cgamma1 signaling pathways
Zhang et al., J Theor Biol 2007 (Brain Neoplasms) : Experimental evidence suggests that epidermal growth factor receptor (EGFR) mediated activation of the signaling protein phospholipase Cgamma plays a critical role in a cancer cell 's phenotypic decision to either proliferate or to migrate at a given point in time
Rodríguez-Fragoso et al., Toxicol Appl Pharmacol 2009 : In the present study we demonstrated that BPQs not only induced EGFR tyrosine autophosphorylation, but also induced EGFR dependent tyrosine phosphorylation of phospholipase C-gamma1 and several signal transducers and activators of transcription ( STATs )
Disatnik et al., Proc Natl Acad Sci U S A 1994 : Additional data indicated that PLC-gamma 1 binds to RACKs in solution ; epidermal growth factor receptor dependent PLC-gamma 1 phosphorylation and activation decreased in the presence of RACKs