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IL1A — PIK3R1
Text-mined interactions from Literome
Schmid et al., Cancer Cell 2011
(Disease Progression...) :
Receptor tyrosine kinases and
TLR/IL1Rs unexpectedly
activate myeloid cell
PI3k? , a single convergent point promoting tumor inflammation and progression
Wu et al., Particle and fibre toxicology 2012
(MAP Kinase Signaling System) :
Pharmacological inhibition of ERK kinase and
PI3K activity
blocked DEP induced IL-8 and
IL-1ß expression
Busch et al., J Biol Chem 2012
:
Resveratrol suppressed
IL-1ß induced activation of NF-?B and
PI3K in a dose- and time dependent manner ...
IL-1ß induced NF-?B and
PI3K activation was inhibited by resveratrol or the inhibitors of PI3K ( wortmannin ), c-Src ( PP1 ), and Akt ( SH-5 ) through inhibition of I?B kinase, I?Ba phosphorylation, and inhibition of nuclear translocation of NF-?B, suggesting that PI3K signaling pathway may be one of the signaling pathways inhibited by resveratrol to abrogate NF-?B activation ... The modulatory effects of resveratrol on
IL-1ß induced
activation of NF-?B and
PI3K were found to be mediated at least in part by the association between Sirt-1 and scleraxis and deacetylation of NF-?B and PI3K