Gene interactions and pathways from curated databases and text-mining

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KRAS — RASA3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: KRAS → RASA3 (directlyIncreases, RASA3 Activity, KRAS Activity)
    Evidence: GAP1m, GAP1IP4BP, CAPRI (Ca2+-promoted Ras inactivator) and RASAL (Ras-GTPase-activating-like protein) [5–8]. Each protein has a basic conserved domain architecture, although subtle variations in the function of each domain have pronounced effects on the regulation of each protein. GAP1 family members contain a centrally located Ras-GAP domain. This is the conserved region found in all Ras-GAPs that contains the catalytic machinery required to enhance the intrinsic GTPase activi...
  • WikiPathways MAPK Cascade: RASA3 → HRAS/NRAS/RRAS/KRAS (activation)