Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
KRAS
→
RASA3
(directlyIncreases, RASA3 Activity, KRAS Activity)
Evidence: GAP1m, GAP1IP4BP, CAPRI (Ca2+-promoted Ras inactivator) and RASAL (Ras-GTPase-activating-like protein) [5–8]. Each protein has a basic conserved domain architecture, although subtle variations in the function of each domain have pronounced effects on the regulation of each protein. GAP1 family members contain a centrally located Ras-GAP domain. This is the conserved region found in all Ras-GAPs that contains the catalytic machinery required to enhance the intrinsic GTPase activi...