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DIO1 — IFNG

Text-mined interactions from Literome

Jakobs et al., Eur J Endocrinol 2002 (Carcinoma, Hepatocellular...) : IL-6 at 500 pg/ml and TNF-alpha at 25 ng/ml had no significant effect, whereas 100 ng/ml IFN-gamma or 10 ng/ml IL-1beta reduced 5'DI enzyme activity to 77.9 and 59.5 % of control values ... IFN-gamma did not alter, IL-6 and TNF-alpha moderately decreased ( in the case of IL-6 only in the CAT system ), and IL-1beta ( 0.01-10 ng/ml ) dose-dependently inhibited 5'DI promoter activity to a minimum of 38.1 %
Tang et al., Endocrinology 1995 : In the present study, we used FRTL5 cells, a cultured rat thyroid follicular cell line, to examine the effects of IFN-gamma and TNF-alpha on type I 5'-deiodinase ( 5'D-I ) activity and 5'D-I, thyroid peroxidase (TPO) and thyroglobulin (Tg) gene expression ... In TSH deprived FRTL-5 cells, TNF-alpha and IFN-gamma resulted in a small but dose dependent decrease in 5'D-I activity ... TNF-alpha or IFN-gamma blocked the TSH- or cAMP induced rise in 5'D-I activity ... 100 ng/ml TNF-alpha and 100 U/ml IFN-gamma completely blocked the TSH- or cAMP induced rise in 5' D-I activity ... Northern blot analyses were performed to examine the effect of TNF-alpha and IFN-gamma on 5'D-I gene expression ... TNF-alpha had little effect on 5'D-I messenger RNA ( mRNA ) levels, while IFN-gamma resulted in a modest decrease in 5'D-I mRNA levels in TSH deprived cells, and in TSH stimulated FRTL-5 cells
Mori et al., Endocrinology 1996 : In the presence of IFN gamma , however, activation of either or both pathways is not sufficient to result in a synergistic inhibition of 5'D-I activity or 5'D-I gene expression