Liu et al., Life Sci 2004
(MAP Kinase Signaling System) :
PGH ( 2 ), PGD ( 2 ) and its metabolites of the PGJ ( 2 ) series, and PGA ( 1 ) markedly induced the protein expression of HO-1 Kim et al., Ann N Y Acad Sci 2004
:
Thus, the induction of HO-1 expression and the activation of Akt/PKB by 15d-PGJ ( 2 ) and PGA ( 2 ) are likely to confer cytoprotective or antiapoptotic effects exerted by these cyPGs