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MMP2 — SMC2
Text-mined interactions from Literome
Pinney et al., J Cardiovasc Pharmacol 2003
(Carotid Artery Injuries) :
In summary, minocycline lowers
MMP-2 expression,
reduces SMC proliferation and migration, and inhibits neointimal hyperplasia, but its efficacy is limited by systemic toxicity
Liu et al., J Vasc Surg 2003
(Aortic Aneurysm, Abdominal) :
This correlated with a decrease in MMP-2 mRNA half-life, from 49 hours to 28 hours, which suggests that doxycycline
inhibits SMC MMP-2 production in part by reducing
MMP-2 mRNA stability
Kothapalli et al., Acta Biomater 2010
(Aneurysm) :
It was observed that
SMC activation with TNF-alpha ( 10 ng ml(-1) ) induced matrix calcification and
promoted production of elastolytic
MMP-2 and MMP-9
Borges et al., Histopathology 2010
(Aortic Aneurysm, Thoracic) :
Because the pericellular fibrinolytic system activation is able to degrade adhesive proteins, activate
matrix metalloproteinase ( MMP ) ,
induce SMC disappearance and increase the bioavailability of TGF-ß, the aim was to investigate the plasminergic system in TAA
Jones et al., J Cell Biol 1997
:
We show that a
matrix metalloproteinase ( MMP ) inhibitor ( GM6001 )
suppresses SMC TN-C expression on native collagen, whereas denatured collagen promotes TN-C expression in a beta 3 integrin- dependent manner, independent of MMPs. Floating type I collagen gel also suppresses SMC MMP activity and TN-C protein synthesis and induces apoptosis, in the presence of EGF
Wang et al., J Vasc Res 1998
:
Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima, and inhibition of this
MMP results in reduced
SMC migration and proliferation, suggesting a role for MMP-2 in neointimal development