◀ Back to IL2

IL2 — VAV1

Text-mined interactions from Literome

Fang et al., J Biol Chem 1999 : SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity ... Furthermore, SLP-76 and Vav have a synergistic effect on interleukin (IL)-2 promoter activity in T cells ... Surprisingly, we find also that the interaction between SLP-76 and Vav is not required for their cooperation in augmenting IL-2 promoter activity, as the two molecules appear to function in different signaling pathways upstream of IL-2 gene expression ... Additionally, overexpression of Vav , but not SLP-76, augments CD28 induced IL-2 promoter activity ... These findings suggest that the synergy between SLP-76 and Vav in regulating IL-2 gene expression reflects the cooperation between different signaling pathways
Penninger et al., Eur J Immunol 1999 : Moreover, Vav has been identified as a major substrate in the CD28 signal transduction pathway and overexpression of Vav enhances TCR mediated IL-2 secretion in T cells
Hofmann et al., Oncogene 2000 : Since Vav1 is essential for IL-2 production and plays a central role for cytoskeletal reorganization, its proteolytic inactivation during apoptosis affects multiple downstream targets
Villalba et al., Immunity 2000 : Vav and PKCtheta play an early and important role in the TCR/CD28 induced stimulation of MAP kinases and activation of the IL-2 gene
Kaminuma et al., Mol Cell Biol 2001 : Vav upregulates the expression of the interleukin-2 (IL-2) gene, primarily via activation of the distal NFAT site in the IL-2 gene promoter ( NFAT-IL-2 ) ... Although Vav stimulated the transcriptional activity of an NFAT-IL-2 reporter gene, it failed to stimulate the transcriptional or DNA binding activities of an AP-1 independent NFAT site derived from the human gamma interferon gene promoter ... These findings indicate that a Rac1 dependent JNK/c-Jun/AP-1 pathway, rather than the Ca ( 2+ ) /NFAT pathway, plays the predominant role in NFAT-IL-2 activation by Vav
Rivera et al., Int Arch Allergy Immunol 2001 : Vav1 deficiency also affected secretion, although not to the extent of LAT deficiency, and inhibited IL-2 and IFN-gamma production
Zakaria et al., J Exp Med 2004 : However, depletion of Vav1 but not Vav3 protein by RNA interference affects TCR mediated IL-2 promoter activity
Wu et al., Immunity 1996 (Leukemia, T-Cell) : Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
Hanazono et al., Acta Haematol 1996 : Here we report that granulocyte/macrophage-colony- stimulating factor ( GM-CSF ), interleukin-3 , and erythropoietin (Epo) induce rapid and transient tyrosine phosphorylation of Vav and that Vav is constitutively associated with the SH3 domain of Grb2/Ash in a human leukemia cell line UT-7
Raab et al., Immunity 1997 : Therefore, despite effects of Vav-SLP-76 on IL-2 expression, Vav-SLP-76 binding per se is not essential for IL-2 production in all T cells
Fischer et al., Curr Biol 1998 : Vav is a crucial regulator of TCR mediated Ca2+ flux, cytoskeletal reorganization and TCR clustering, and these are required for T-cell maturation, interleukin-2 production and cell cycle progression