◀ Back to TRAF2
TANK — TRAF2
Pathways - manually collected, often from reviews:
-
BioCarta tnfr2 signaling pathway:
TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1)
→
MEKK1 (MAP3K1)
(modification, activates)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
MAP4K2
(modification, activates)
-
BioCarta tnf/stress related signaling:
SODD (BAG4)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
I-TRAF (TANK)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRADD
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
I-TRAF (TANK)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta tnfr2 signaling pathway:
TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1)
→
MAP3K14
(modification, activates)
-
BioCarta tnfr2 signaling pathway:
TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TRAF3-TRAF2-RIPK1-TNFRSF1B-TRAF1)
→
TNF-beta (LTA)
(modification, collaborate)
-
BioCarta tnfr2 signaling pathway:
TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TRAF3-TRAF2-RIPK1-TNFRSF1B-TRAF1)
→
TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1)
(modification, collaborate)
-
BioCarta tnfr2 signaling pathway:
TNF-beta (LTA)
→
TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1)
(modification, collaborate)
-
Reactome Reaction:
TANK
→
TRAF2
(indirect_complex)
Guo et al., J Biol Chem 2007, Konno et al., PloS one 2009, Kawagoe et al., Nat Immunol 2009*
-
Reactome Reaction:
TANK
→
TRAF2
(reaction)
Paz et al., Cell Mol Biol Incl Cyto Enzymol 2006, Guo et al., J Biol Chem 2007, Konno et al., PloS one 2009, Kawagoe et al., Nat Immunol 2009*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(direct interaction, pull down)
Li et al., Structure 2002*
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Li et al., Immunity 2011
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Shen et al., Mol Cell Biol 2012
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(direct interaction, two hybrid)
Rothe et al., Proc Natl Acad Sci U S A 1996*
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Rothe et al., Proc Natl Acad Sci U S A 1996*
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Nomura et al., Genes Cells 2000*
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Pomerantz et al., EMBO J 1999
-
IRef Biogrid Interaction:
TRAF2
—
TANK
(physical association, affinity chromatography technology)
Behrends et al., Nature 2010
-
MIPS CORUM TANK-TRAF2-TRAF3 complex:
TANK-TRAF2-TRAF3 complex complex (TANK-TRAF2-TRAF3)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM Kinase maturation complex 2:
Kinase maturation complex 2 complex (AZI2-CDC37-HSP90AA1-HSP90AB1-TANK-TBK1-TBKBP1-TRAF2)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of TANK-TRAF3-TRAF2-TANK-TRAF3-TRAF2
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 17 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Dip Interaction:
TANK
—
TRAF2
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
TRAF2
—
TANK
(two hybrid)
Rothe et al., Proc Natl Acad Sci U S A 1996*
-
IRef Hprd Interaction:
TRAF2
—
TANK
(in vitro)
Rothe et al., Proc Natl Acad Sci U S A 1996*
-
IRef Hprd Interaction:
TRAF2
—
TANK
(in vivo)
Rothe et al., Proc Natl Acad Sci U S A 1996*
-
IRef Hprd Interaction:
Complex of 57 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Pomerantz et al., EMBO J 1999
-
IRef Hprd Interaction:
Complex of TRAF2-TANK-TRAF3-TRAF3-TANK-TRAF2-TANK-TRAF2-TRAF3
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
TANK
—
TRAF2
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
TANK
—
TRAF2
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
Complex of 11 proteins
(physical association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of 22 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of BIRC2-TRAF2-TBK1-TRAF3-APBA3-TANK
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of 21 proteins
(association, anti tag coimmunoprecipitation)
Goncharov et al., EMBO J 2013
-
IRef Intact Interaction:
Complex of 19 proteins
(association, anti tag coimmunoprecipitation)
Goncharov et al., EMBO J 2013
-
IRef Ophid Interaction:
TANK
—
TRAF2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Chaudhuri et al., Biochem Biophys Res Commun 1999
:
We conclude from these studies that the phosphorylation of
TRAF2 is likely to play an important role in regulating signaling by virtue of its ability to
influence the
CD40-TRAF2 interaction
Leonardi et al., J Biol Chem 2000
:
TRAF2 is required for TNF induced activation of c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ), and
TRAF2 can also
mediate activation of NF-kappaB
Zhu et al., Cytokine 2010
(Glomerulonephritis...) :
Knockdown
TRAF-2 by siRNA significantly
suppressed soluble AIgG induced up-regulation of
TRAF-2 , IL-1beta, and IL-6