Nakayama et al., J Bone Miner Res 2003
:
FGF-2 and EGF inhibited alkaline phosphatase activity and Smad6 promoter activity stimulated by BMP-2
Cushing et al., FASEB J 2008
(Fibrosis...) :
Using an exogenous Smad-responsive transcriptional promoter reporter, we show that Smad activity is repressed by FGF-2 , likely an effect of the fact that FGF-2 treatment prevents the nuclear localization of Smads in these cells
Stuhlmiller et al., Development 2012
:
Our results identify an early requirement for FGF/MAPK signaling in amniote neural crest induction and suggest an intriguing role for FGF mediated Smad inhibition in ectodermal development