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CCL2 — FGB

Text-mined interactions from Literome

Smiley et al., J Immunol 2001 : Differential mRNA expression analysis and RNase protection assays revealed that macrophage inflammatory protein-1alpha ( MIP-1alpha ), MIP-1beta, MIP-2, and monocyte chemoattractant protein-1 are fibrinogen inducible in the RAW264.7 mouse macrophage-like cell line, and ELISA confirmed that both RAW264.7 cells and primary murine thioglycolate elicited peritoneal macrophages up-regulate the secretion of monocyte chemoattractant protein-1 > 100-fold upon exposure to fibrinogen
Szaba et al., Blood 2002 (Disease Models, Animal...) : This study also suggests that fibrin regulates chemokine/cytokine production in vivo, as direct injection of thrombin stimulated peritoneal accumulation of IL-6 and MCP-1 in a fibrin(ogen) dependent manner
Guo et al., Thromb Haemost 2004 (Inflammation) : Parthenolide, an IkappaB kinase inhibitor, prevented up-regulation of MCP-1 by fibrinogen , linking this response to NF-kappaB activation
Thacker et al., Exp Mol Pathol 2008 : Adsorbed fibrinogen increased dendritic cell expression of IL-6, IL-8, MIP-1beta and MCP-1
Motojima et al., Nephron. Experimental nephrology 2010 (Proteinuria) : Knockdown of TLR2 and TLR4 inhibited the fibrinogen induced MCP-1 mRNA upregulation