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BDNF — SMAD1

Text-mined interactions from Literome

Chaverneff et al., J Neurochem 2009 (Hypoglycemia) : Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress ... BDNF increased both Akt and Erk phosphorylation, but pharmacological blockade of these kinase pathways ( with wortmannin and U0126, respectively ) did not reduce the Smad phosphorylation produced by the BMP7 + BDNF combination ... These findings suggest that BDNF can increase BMP dependent Smad phosphorylation via a mechanism requiring CK2
Ji et al., Neuron 2012 : Axon derived SMAD1/5/8 is translocated to the cell body, where it is phosphorylated to a transcriptionally active form by BMP4 induced signaling endosomes and mediates the transcriptional effects of target derived BDNF and BMP4