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HNF4A — IL1B

Text-mined interactions from Literome

Jahan et al., Am J Physiol Gastrointest Liver Physiol 2005 (MAP Kinase Signaling System) : A dominant negative HNF4alpha inhibited CYP8B1 gene transcription and ectopically expressed HNF4alpha blocked IL-1beta inhibition ... Furthermore, IL-1beta inhibited HNF4alpha gene transcription, protein expression, and binding to the CYP8B1 gene ... JNK1 phosphorylated HNF4alpha and a JNK-specific inhibitor blocked the IL-1beta inhibition of HNF4alpha expression
Guo et al., Biochem J 2006 (Inflammation) : Our results indicate that p38 kinase mediated Ser158 phosphorylation is essential for augmentation of the DNA binding and transactivation potential of HNF4alpha in the presence of IL-1beta+H2O2
Li et al., Hepatology 2006 : Co-immunoprecipitation and ChIP assays revealed that IL-1 beta and CDCA reduced HNF4 alpha bound to the CYP7A1 chromatin, and that c-Jun interacted with HNF4 alpha and blocked HNF4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin ... In conclusion, IL-1 beta and CDCA inhibit HNF4 alpha but induce c-Jun, which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription
Krajewski et al., Cell Mol Life Sci 2007 (Anemia) : Interleukin-1beta inhibits the hypoxic inducibility of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha ... IL-1beta inhibited HNF-4alpha mRNA expression and caused proteasome dependent degradation of HNF-4alpha protein, which resulted in a strongly reduced DNA binding activity of HNF-4alpha