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IL1B — PAPPA

Text-mined interactions from Literome

Conover et al., Bone 2004 : Tumor necrosis factor alpha (TNFalpha), IL-1beta , and IL-4 also increased PAPP-A expression 3- to 4-fold
Resch et al., Endocrinology 2006 (Second Messenger Systems) : An inhibitor of p38 activation ( SB203580 ) had no effect on TNFalpha- or IL-1beta stimulated PAPP-A expression ... However, SP600125 effectively inhibited IL-1beta induced PAPP-A protein expression ... BAY11-7082, another inhibitor of NFkappaB activation, also inhibited TNFalpha- and IL-1beta stimulated PAPP-A expression and IGF binding protein-4 protease activity
Conover et al., Am J Physiol Cell Physiol 2006 : Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta stimulated PAPP-A gene expression in a time- and dose dependent manner ... Interestingly, pretreatment of hCASMC with resveratrol, a polyphenol found in the skin of grapes and in red wine purported to underlie the `` French paradox, '' inhibited TNF-alpha- and IL-1beta induced PAPP-A expression and, hence, its IGFBP-4 proteolytic activity ... Our finding that PAPP-A gene expression in hCASMC is stimulated by TNF-alpha and IL-1beta suggests a mechanism for the regulation of PAPP-A in response to vascular injury that may contribute to the enhanced IGF-I bioactivity in intimal hyperplasia and atherosclerotic plaque development