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HDAC3 — RBBP4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC3
—
RBBP4
(direct interaction, pull down)
Nicolas et al., Nucleic Acids Res 2001
-
IRef Hprd Interaction:
HDAC3
—
RBBP4
(in vivo)
Nicolas et al., Nucleic Acids Res 2001, Johnson et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
HDAC3
—
RBBP4
(in vitro)
Nicolas et al., Nucleic Acids Res 2001, Johnson et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
Complex of 243 proteins
(in vivo)
Takezawa et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of 31 proteins
(association, anti bait coimmunoprecipitation)
Litovchick et al., Mol Cell 2007
-
IRef Intact Interaction:
Complex of RBBP4-SIN3A-HDAC3-HDAC4
(association, anti tag coimmunoprecipitation)
Grozinger et al., Proc Natl Acad Sci U S A 1999
Text-mined interactions from Literome
Sargeant et al., Cancer Res 2008
(Adenocarcinoma...) :
OSU-HDAC42 , a
histone deacetylase inhibitor , blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model
Wang et al., Biochem Pharmacol 2010
:
Here we demonstrate that ferritin H mRNA and protein are induced by
histone deacetylase inhibitors (
HDAC inhibitors ), a promising class of anti-cancer drugs, in cultured human cancer cells
Alamdari et al., Am J Physiol Regul Integr Comp Physiol 2010
(Disease Models, Animal...) :
Treatment of rats with dexamethasone increased expression of p300 and HAT activity, reduced expression of
HDAC3 and -6, and
inhibited HDAC activity
Lee et al., Circ Res 2013
(Disease Models, Animal...) :
HDAC inhibition promoted MR acetylation, leading to decreased transcriptional activity of MR. Knockdown or inhibition of
HDAC3 resulted in reduced expression of MR target genes induced by mineralocorticoids