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IGF1R — PRKAG1
Text-mined interactions from Literome
Raile et al., Diabetologia 2005
(Insulinoma...) :
Activation of
AMPK by 5-amino-imidazolecarboxamide riboside ( AICAR, 0.5 mmol/l ) suppressed Pklr expression, but strongly
stimulated gene expression of
Igf1r , Insr and Insrr ... Stimulation of Igf1r and Insr gene expression by the AMPK-activator AICAR might indicate
involvement of
AMPK in the regulation of
Igf1r , Insr and Insrr expression in beta cells
Memmott et al., Cancer prevention research (Philadelphia, Pa.) 2010
(Carcinoma...) :
In lung tissue, metformin did not activate
AMPK but
inhibited phosphorylation of
insulin-like growth factor-I receptor/insulin receptor ( IGF-1R/IR ), Akt, extracellular signal regulated kinase ( ERK ), and mTOR
Leclerc et al., Journal of molecular signaling 2010
:
We determined that activation of P-Akt ( Thr308 ) was mediated by
AMPK induced
IGF-1R activation via phosphorylation of the insulin receptor substrate-1 (IRS-1) at Ser794