Gene interactions and pathways from curated databases and text-mining

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MYC — PTTG1

Text-mined interactions from Literome

Yan et al., Cancer Res 2009 (Carcinoma, Squamous Cell...) : PTTG activated E-box transcription and induced c-Myc protein expression in EC9706 cells, which in turn may act on an E-box motif within the galectin-1 promoter
Tong et al., J Mol Endocrinol 2009 : PTTG1 activates c-Myc in NIH 3T3 cells, suggesting a role in cell transformation
Chintharlapalli et al., Mol Carcinog 2011 (Thyroid Neoplasms) : In addition, pituitary tumor transforming gene-1 ( PTTG-1 ) protein and mRNA levels were also decreased in thyroid cancer cells treated with CDODA-Me or CF ( 3 ) DODA-Me and this was accompanied by decreased expression of PTTG-1 dependent c-Myc and fibroblast growth factor-2 (FGF-2) genes