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IFNG — PSMB8
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sewell et al., J Immunol 1999
:
Consistent with these observations we show that
up-regulation of
LMP7 by
IFN-gamma enhances presentation of the VIYQYMDDL epitope
Lee et al., Cancer Res 2000
(Neoplasm Metastasis...) :
IFN-gamma induced surface class I MHC expression, as well as gene expression of TAP-1, TAP-2, LMP-2, and
LMP-7 in the metastatic cells, yet the cells remained resistant to cell lysis induced by CTLs. Interestingly, although in comparison to the primary cells the metastatic cells were resistant to cytolysis, both cell types were susceptible to DNA fragmentation induced by CTLs. Cell fusion between primary and metastatic cancer cells resulted in hybrids that also resisted the cytolytic activity of CTLs
van Hall T et al., J Exp Med 2000
:
Interferon (IFN)-gamma induces expression of three catalytically active proteasome subunits ( LMP2,
LMP7 , and MECL-1 ) and the proteasome associated activator PA28
Namiki et al., FEBS Lett 2005
:
IRF-1 mediates
upregulation of
LMP7 by
IFN-gamma and concerted expression of immunosubunits of the proteasome ... We demonstrate that interferon (IFN) regulatory factor-1 ( IRF-1 ) has a pivotal role in
IFN-gamma dependent
LMP7 expression, as was shown for the other two immunosubunits
Heink et al., Cancer Res 2006
(Cell Transformation, Neoplastic...) :
Here, we report that human cancer cells express the nonfunctional immunosubunit-variant
LMP7E1 , in addition to, or instead of LMP7E2, in
response to
IFN-gamma
Früh et al., EMBO J 1994
:
In the experiments reported in this communication we studied the subunit changes occurring in cell lines where the expression of LMP2 or
LMP7 can be
regulated individually either by
IFN-gamma induction or by applying a new system to control the expression of transfected LMPs
Gaczynska et al., J Biol Chem 1996
:
Proteasome subunits X and Y alter peptidase activities in opposite ways to the
interferon-gamma induced subunits LMP2 and
LMP7