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CTGF — MAPK3

Text-mined interactions from Literome

Yosimichi et al., Eur J Biochem 2001 : In the proliferation phase, CTGF/Hcs24 induced a approximately fivefold increase in the phosphorylation of p44/42 MAPK/ERK and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay
Sohn et al., Kidney Int 2005 : Inhibition of p38 ( mapk ) or p42/44(mapk) activities did not affect LDL induced TGF-beta1, CTGF , and collagen I expression, whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta, CTGF, and collagen I expression
Liu et al., J Cell Biochem 2006 : Inhibitors of ERK1/2 and JNK but not p38MAPK inhibited the BK- and AngII stimulated expression of CTGF in cells expressing either the WT or mutant receptors, illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein
Mulsow et al., Ann Surg 2005 (Crohn Disease...) : ERK 1/2 inhibition had a similar effect on TGF-beta induced CTGF and fibronectin expression
Wu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006 : CTGF increased the p42/44MAPK phosphorylation ... Pretreatment of the cells with PD98059 or UO126, inhibitors of phosphorylated p42/44 MAKP, decreased the CTGF induced expression of phosphorylated p42/44 MAPK and concentration of FLK in supernatants
Wu et al., Kidney Int 2006 : CTGF enhanced the mRNA expression and protein release of fractalkine, MCP-1, and RANTES, the expression of phospho ( P ) -p42/44 mitogen activated protein kinase ( MAPK ), P-phosphoinositide 3-kinase (PI3-K), P-Akt, and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells ... P-p42/44 MAPK blockade inhibited the CTGF induced expression of P-p42/44 MAPK but not NF-kappaB, and partially decreased the levels of the above chemokines in supernatants ... P-PI3-K blockade downregulated the CTGF stimulated expression of P-PI3-K, P-Akt, and NF-kappaB but not P-p42/44 MAPK , and partially decreased the release of the above chemokines ... LXA ( 4 ) dose-dependently inhibited the CTGF stimulated mRNA expression and protein release of the above chemokines, and the expression of P-p42/44MAPK , P-PI3-K, P-Akt, and NF-kappaB
Chien et al., Mol Cancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : Most interestingly, overexpression of CTGF suppressed insulin-like growth factor-I dependent Akt phosphorylation and epidermal growth factor dependent extracellular signal regulated kinase 1/2 phosphorylation
Hong et al., J Cell Biochem 2007 (Diabetes Mellitus, Type 2...) : Glucose and insulin induced ERK 1/2 phosphorylation also stimulated connective tissue growth factor gene expression
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : The MAPK inhibitor, U0126, blocked MMP-1 activity and restored HGF inhibited collagen and CTGF accumulation
Kanno et al., Am J Pathol 2010 (Disease Progression...) : Moreover, we found that connective tissue growth factor induced the expression of alpha2AP through both the extracellular signal regulated kinase 1/2 ( ERK1/2 ) and c-Jun N-terminal kinase (JNK) pathways in fibroblasts
Browne et al., Invest Ophthalmol Vis Sci 2011 (Exfoliation Syndrome...) : Western blot analysis demonstrated increased phosphorylation of p42/44 MAPK, p38 MAPK , and the JNK pathways in response to CTGF
Guo et al., Chin Med J (Engl) 2010 (Fibrosis...) : The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on MAPK phosphorylation, and the effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and CTGF expression were detected by immunoblotting assay
Ding et al., Cell Signal 2013 : Taken together, our results provide evidence for the role of HPCs in liver fibrosis and suggest that the production of CTGF by TGF-ß activated MAPK signaling in HPCs may be a therapeutic target of liver fibrosis