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EGF — PXN
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rhee et al., Mol Cells 2000
:
Major
effects of
EGF/K252a , found also in the NGF treated cells, are the sustained mobility shift of paxillin in SDS-PAGE and the promoted association of Crk-II with
paxillin
Terfera et al., J Cell Physiol 2002
:
The experiments in this report were designed to determine the
effect of
EGF on
paxillin phosphorylation in normal rat kidney (NRK) epithelial cells ... In addition, the
EGF stimulated change in
paxillin serine/threonine phosphorylation was not accompanied by a profound reorganization of the actin cytoskeleton
Chen et al., Mol Cell Biol 2004
:
In the present study, we not only identified paxillin as the binding partner and substrate of Brk but also discovered a novel signaling pathway by which Brk mediates
epidermal growth factor (EGF) induced
paxillin phosphorylation ... We show that
EGF stimulation
activates the catalytic activity of Brk, which in turn phosphorylates
paxillin at Y31 and Y118
Zhong et al., Endocr Relat Cancer 2005
(Neoplasm Invasiveness...) :
Lovastatin also reduced
EGF induced increases in the levels of phosphorylated p125(FAK) and
paxillin
Park et al., Cell Signal 2007
(Calcium Signaling) :
EGF induced a dynamic reorganization of RAFTK and paxillin at neuronal adhesion sites, with the specific localization of
paxillin at the inner juxtaposition of RAFTK
Huang et al., Cell Signal 2008
(MAP Kinase Signaling System) :
Here, the migration of human corneal epithelial (HCE) cells was used to determine which signaling pathways are involved in
EGF induced
paxillin phosphorylation ...
Paxillin was phosphorylated on Tyr 31 and Tyr 118 after
induction of migration by
EGF in HCE cells
Schneider et al., Mol Biol Cell 2009
:
Inhibition of myosin-II blocked both the
EGF stimulated
paxillin phosphorylation and cell retraction, and a paxillin phosphomimic blocked retraction
Sen et al., J Clin Invest 2012
(MAP Kinase Signaling System...) :
We show that androgen and
EGF promoted MAPK dependent phosphorylation of
paxillin , resulting in nuclear translocation of paxillin
Khan et al., Eur J Biochem 1996
:
Tyrosine phosphorylation of
paxillin was also
induced by nerve growth factor and
epidermal growth factor , but its migration patterns on an SDS/polyacrylamide gel were different, that is, nerve growth factor and epidermal growth factor caused upward shifts of the bands, while KC1 did not
Tapia et al., Biochim Biophys Acta 1999
:
EGF stimulates tyrosine phosphorylation of focal adhesion kinase ( p125FAK ) and
paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on phosphatidylinositol 3-kinase, the small GTP binding protein, p21rho, and the integrity of the actin cytoskeleton ... However, inhibition of the phosphatidylinositol 3-kinase ( PI3-kinase ) or inactivation of p21rho inhibited
EGF stimulated phosphorylation of p125FAK and
paxillin by more than 70 %