Takeda et al., Hum Mol Genet 2000
(Waardenburg Syndrome) :
The same serine was found to be phosphorylated in vivo, and expression of dominant negative GSK3beta selectively suppressed the ability of MITF to transactivate the tyrosinase promoter
Hetman et al., J Biol Chem 2002
:
Furthermore, ERK1/2 inhibits GSK3beta activity via a novel mechanism that is independent of Ser-9 phosphorylation and likely does not involve Tyr-216 phosphorylation
Dozza et al., J Neurochem 2004
(Neuroblastoma) :
GSK3beta activity is regulated by Ser9 ( inhibitory ) and Tyr216 ( stimulatory ) phosphorylation
Lee et al., Mol Cells 2008
:
Thus, our observations indicate that GSK 3beta binds to Fe65 through its ( 371 ) PPLA ( 374 ) motif and that this interaction regulates apoptosis and phosphorylation of Tyr 216 of GSK 3beta