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GPX3 — NFKB1
Pathways - manually collected, often from reviews:
-
WikiPathways Oxidative Stress:
NFKB1/SP1/NFE2L2
→
HMOX1/GPX1/GPX3/NQO1/UGT1A6
(activation)
Text-mined interactions from Literome
Zhou et al., Free Radic Biol Med 2001
:
To test whether
NF kappa B or AP-1 might be
mediating the induction of
GPx and CAT in muscle cells subjected to oxidative stress, we first characterized their activation by pro-oxidants ... In summary, our results suggest that NF kappa B and AP-1 are important mediators of redox-responsive gene expression in skeletal muscle, and that at least
NF kappa B is actively
involved in the upregulation of the
GPx and CAT in response to oxidative stress
ViƱa et al., Biol Chem 2008
:
Activation of
NF-kappa B by estrogens subsequently
activates the expression of Mn-SOD and
GPx , but genistein is only capable of activating Mn-SOD expression
Kretz-Remy et al., J Cell Biol 1996
:
Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent
NF-kappa B activation by
glutathione peroxidase overexpression