Aijaz et al., Dev Cell 2005
:
Binding of GEF-H1 to the tight junction associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition
Birkenfeld et al., Dev Cell 2007
:
Using a live cell biosensor, we demonstrate distinct roles for GEF-H1 and Ect2 in regulating Rho activity in the cleavage furrow, with GEF-H1 catalyzing Rho activation in response to Ect2 dependent localization and initiation of cell cleavage
Waheed et al., Am J Physiol Cell Physiol 2010
:
Extracellular signal regulated kinase and GEF-H1 mediate depolarization induced Rho activation and paracellular permeability increase
Kratzer et al., Am J Respir Cell Mol Biol 2012
(Acute Lung Injury) :
These studies demonstrate, for the first time, the mechanism of ROS induced Rho activation via destabilization of MTs and GEF-H1 dependent activation of Rho signaling, leading to pulmonary EC barrier dysfunction and exacerbation of LPS induced inflammation