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ATF2 — MMP2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Song et al., Cancer Res 2006
(Breast Neoplasms...) :
Activating transcription factor 2 mediates
matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells
Kim et al., Cancer Lett 2007
(Breast Neoplasms...) :
TGF-beta induced transcriptional activation of
MMP-2 is
mediated by activating transcription factor
(ATF)2 in human breast epithelial cells ... Since activating transcription factor (ATF)2 was shown to mediate the TGF-beta induced cellular responses, we examined the
involvement of
ATF2 in TGF-beta activated
MMP-2 gene transcription ... A dominant negative ( DN )
ATF2 significantly
inhibited the TGF-beta induced up-regulation of
MMP-2 , but not that of MMP-9, suggesting that ATF2 may be a transcription factor responsible for transcriptional activation of MMP-2 gene by TGF-beta ... Taken together, this study demonstrates that
ATF2 mediates the TGF-beta induced
MMP-2 transcriptional activation, elucidating a molecular mechanism for the malignant progression of human breast epithelial cells exerted by TGF-beta
Lee et al., J Dermatol Sci 2013
:
In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent
activation of mitogen activated protein kinase ( MAPK ),
ATF-2 , and c-Jun, and
MMP expression