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EGFR — MAP2K1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Am J Physiol Lung Cell Mol Physiol 2002
(MAP Kinase Signaling System) :
In summary, exposure to As, Zn, and V initiated
EGFR signaling and Ras dependent
activation of
MEK1/2 and ERK1/2, but only V induced Ras dependent NF-kappaB nuclear translocation
Huang et al., J Biol Chem 2003
:
This GH-induced
EGFR phosphorylation was
prevented by
MEK1 inhibitors but not by a protein kinase C inhibitor
Li et al., Cell Signal 2008
(Fibrosarcoma) :
Additionally,
EGFR undergoes
MEK1 dependent ERK consensus site phosphorylation in response to EGF or cytokines such as growth hormone (GH) and prolactin (PRL)
Arita et al., J Gen Virol 2009
:
We identified
MEK1/2 inhibitors ( SL327 and U0126 ), an
EGFR inhibitor ( AG1478 ) and a phosphatidylinositol 3-kinase inhibitor ( wortmannin ) as compounds with a cooperative inhibitory effect with GW5074, and an Akt1/2 inhibitor ( Akt inhibitor VIII ) as a compound with a synthetic inhibitory effect with MEK1/2 inhibitors and AG1478
Morrison et al., J Biol Chem 1996
:
Role of
mitogen activated protein kinase kinase in regulation of the
epidermal growth factor receptor by protein kinase C