◀ Back to CDKN1A

CDKN1A — FGF2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → FGF2 (increases) Johnson et al., Oncogene 1998*
  Evidence: FGF2 induced increase in p21/waf1 levels in MCF-7 cells. Whereas, in T47D cells under the same condition showed no detectable induction of p21 by FGF. FGF7 also increased the levels of p21, but to a lesser extent.

Text-mined interactions from Literome

Kivinen et al., Cell Growth Differ 1999 : We show here that fibroblast growth factor-2 (FGF-2) , platelet derived growth factor ( PDGF ), and transforming growth factor-beta1 ( TGF-beta1 ) all induce p21 expression in mouse fibroblasts, but with markedly different kinetics ... In contrast, FGF-2 regulation of p21 is largely independent of MEK and Ras
Aikawa et al., J Biol Chem 2001 (Chondrosarcoma) : FGF2 increased p21 expression in RCS cells, which assembled with the cyclin E-Cdk2 complexes, although the expression of neither cyclin E nor Cdk2 increased ... FGF2 not only induced p21 protein expression in proliferating chondrocytes in mouse fetal limbs cultured in vitro but also decreased their proliferation as assessed by the expression of histone H4 mRNA, a marker for cells in S phase
Fenig et al., Breast Cancer Res Treat 2001 (Breast Neoplasms...) : In contrast, antisense oligonucleotides to TGFbeta1 abrogated the antiproliferative effects and inhibited the induction of p21/WAF1/Cip1 by bFGF in MCF-7 cells
Bellosta et al., J Bone Miner Res 2003 : We studied the expression of several cell cycle regulatory molecules in response to fibroblast growth factor, and found that fibroblast growth factor strongly upregulates the expression of p21 ( WAF1/CIP1 ), a CDK inhibitor that has also been implicated in the regulation of apoptosis and cell differentiation
Muroya et al., Oncogene 1992 : In contrast, basic fibroblast growth factor , interleukin 6 and dibutyryl cAMP, which induce neuronal differentiation of PC12 cells, did not stimulate the accumulation of p21-GTP at any time point examined
Chaturvedi et al., Endocrinology 2005 : The Src kinase inhibitor PP1 also reduced bFGF activation of Ras p21 and cell proliferation in PR1 cells ... These data suggest that bFGF induction of lactotropic cell proliferation is possibly mediated by activation of Src kinase, Ras p21 , and MAPK p44/42
Kim et al., Angiogenesis 2005 : In Western blot analysis, bFGF induced cytoplasmic translocation of p21 ( Waf1/Cip1 ) and p27 ( Kip1 ) and phosphorylation of p27 ( Kip1 ) but rk-2 treatment inhibited translocation of p21 ( Waf1/Cip1 ) and p27 ( Kip1 ) from nucleus to cytoplasm and phosphorylation of p27 ( Kip1 )
Ding et al., J Huazhong Univ Sci Technolog Med Sci 2008 (Carcinoma, Adenoid Cystic...) : MTT demonstrated ACC-2 cell proliferation was substantially enhanced by bFGF, immuno-precipitation displayed ERK activity was up-regulated by bFGF, and immuno imprinting also showed p-ERK ( 1/2 ), cyclin D1 expression was greatly enhanced and p21 ( waf/cip1 ) expression was inhibited by bFGF
Johnson et al., Oncogene 1998 (Breast Neoplasms...) : FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells