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OCLN — TNF

Text-mined interactions from Literome

Wachtel et al., J Neurochem 2001 : Removal of TNF from astrocytes restored the basal level of occludin
Siu et al., Endocrinology 2003 : TNFalpha also inhibited the timely induction of occludin , which is known to associate with the Sertoli cell TJ-barrier assembly
Cui et al., Zhonghua Nei Ke Za Zhi 2007 (Disease Models, Animal...) : The reduction of tight junction protein occludin in intestinal epithelial cells may be a result of the production of TNFalpha in mice with fulminant hepatic failure
Kimura et al., Invest Ophthalmol Vis Sci 2008 : The abundance of neither ZO-1 nor occludin was affected by TNF-alpha
Cui et al., Braz J Med Biol Res 2010 : Western blot results indicated that TNF-alpha decreased the expression of phosphorylated occludin in detergent-insoluble fractions but did not affect the expression of non phosphorylated occludin protein
Fischer et al., Am J Physiol Gastrointest Liver Physiol 2013 : In addition, TNF-a induced a downregulation of claudin-1, claudin-2, claudin-4, and occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells, which was reversed by adalimumab
Hardyman et al., J Allergy Clin Immunol 2013 (Asthma) : TNF-a lowered transepithelial electrical resistance and increased fluorescent dextran permeability, caused loss of occludin and claudins from tight junctions with redistribution of p120 catenin and E-cadherin from adherens junctions, and also increased endogenous TNF-a, IL-6, IL-1ß, IL-8, thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release