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PLA2G1B — TNF

Text-mined interactions from Literome

Yucel-Lindberg et al., J Dent Res 1999 : The study indicates that the synergistic stimulation of prostaglandin production by IL-1beta, and TNFalpha is mediated partly at the level of COX-2 and partly at the level of PLA2 and that PKC is involved in the signal transduction of the synergy between the two cytokines
Heyninck et al., Anticancer Res 1999 (Fibrosarcoma...) : The reduced TNF-sensitivity of A20 expressing L929 cells was correlated with a decrease of TNF induced phospholipase A2 (PLA2) , phospholipase C (PLC) and phospholipase D ( PLD ) activation
El Mahdani et al., J Immunol 2000 : Although a significant inhibitory effect of MAFP on both TNF induced AA release and PLA(2) activity in MCF7 was observed, BEL had no effect
Mollapour et al., Blood 2001 (MAP Kinase Signaling System) : On the other hand, SB203580 inhibited FMLP-superoxide responses in unprimed as well as TNF-alpha- and GM-CSF primed neutrophils, but failed to inhibit TNF-alpha- and GM-CSF primed PLA(2) responses stimulated by FMLP, and additionally enhanced A23187 stimulated arachidonate release, showing that priming and activation of PLA(2) and NADPH oxidase are differentially dependent on both the p38 ( SAPK ) and p42 ( ERK2 ) pathways
Vadas et al., Infect Immun 1992 (Malaria) : Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2) , we examined serum PLA2 levels in 14 adults with malaria
Varastehpour et al., J Clin Endocrinol Metab 2006 (Fetal Diseases...) : TNF-alpha and leptin both induced a time dependent activation of PLA2G2 and PLA2G5 in placental cells
Goppelt-Struebe et al., Biochim Biophys Acta 1992 : Glucocorticoids only moderately reduced PLA2 activity in control cells, but completely inhibited the TNF alpha induced increase in the activity of the high-molecular-weight cytosolic PLA2
Nakano et al., FEBS Lett 1990 (Vasculitis) : cAMP elevating agents also stimulated the release of PLA2 and increased the mRNA, but IL-1, TNF and LPS did not affect cAMP levels
Hollenbach et al., J Biol Chem 1992 : In this report we have examined the ability of tumor necrosis factor-alpha (TNF) to induce the activity of phospholipase A2 (PLA2) in the cell line C3HA, a murine 3T3-like cell line which is normally resistant to TNF induced cytolysis but can be sensitized with inhibitors of transcription and translation ... Our results show that TNF is normally unable to induce the activity of PLA2 in this cell, as measured by the release of [ 3H ] arachidonic acid ... We find, however, that in the presence of either actinomycin D ( Act D ) or cycloheximide ( CHI ), TNF is indeed able to induce phospholipase activity and that the TNF induced activation of PLA2 occurs 2-4 h before the onset of 51Cr release ... Treatment with dexamethasone also inhibited cytolysis by 40-50 % indicating that the CHI dependent , TNF induced activation of PLA2 is a cause, not an effect of cytolysis ... The ability of TNF to induce the activity of PLA2 was also tested in two other cell types which are resistant to TNF except in the presence of Act D or CHI : SK-MEL-28, a human melanoma derived cell line, and pVBETK-1cl15.2, an SV40 transformed murine L cell line ... Our results were the same, treatment with a combination of Act D and TNF or CHI and TNF was required to cause activation of PLA2
Chenevier-Gobeaux et al., Life Sci 2007 (Arthritis, Rheumatoid...) : Basal PLA(2) activity was significantly more important in RA cells than in OA cells ; PLA(2) activity was increased in IL-1beta and TNF-alpha pre treated RA cells, and cPLA(2) inhibitors inhibited this activity
Shimizu et al., Biochem Pharmacol 2008 : To find out the mechanisms underlying the TNFalpha induced release of AA, we investigated the relationship between TNFalpha stimulation and PLA(2) regulation with and without zVAD, an inhibitor of caspases
Bauldry et al., J Immunol 1991 : We investigated these possibilities in TNF-alpha priming of PMN and report that TNF-alpha had no direct effect on PLA2 activation or metabolite formation
Oka et al., J Biol Chem 1991 : Agents which increase intracellular cAMP concentration did not stimulate PLA2-II expression by themselves but selectively enhanced TNF induced PLA2-II expression about 5-fold ... H-7, a protein kinase C inhibitor, inhibited the LPS induced PLA2-II expression, but did not inhibit the TNF induced one
Nakano et al., J Biol Chem 1990 (Inflammation) : Both forskolin induced and tumor necrosis factor (TNF) induced PLA2 release responses were almost completely blocked by 10 and 100 nM dexamethasone, respectively, as assayed by protein blotting and PLA2 activity assays ... Inhibition of TNF induced PLA2 release by glucocorticoids may be explained by the blocking of post-transcriptional synthesis of the group II PLA2
Stevens et al., Agents Actions 1989 : The effects of recombinant interleukin-1 beta ( rIL-1 beta ), recombinant tumor necrosis factor ( rTNF alpha ) and two growth factors, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) on PLA2 activity and prostaglandin E2 ( PGE2 ) release were investigated using rabbit chondrocytes
Godfrey et al., Prostaglandins 1988 (Osteoarthritis) : These data show that tumor necrosis factor and interleukin-1 can both activate synovial cell PLA2 and induce generation of PGE2, but act in an additive rather than a synergistic fashion
Gilman et al., J Rheumatol 1987 : In contrast to IL-1, neither IL-2 nor tumor necrosis factor alpha (TNF alpha) activated PLA2 , PGE2, or neutral protease secretion in these cells and neither of these cytokines inhibited the chondrocyte metabolic response to IL-1
Bomalaski et al., J Immunol 1995 : PLAP stimulation of TNF and IL-1 could be enhanced with co-treatment of cells with free fatty acids, such as arachidonic or linoleic acid, but it was not blocked completely by PLA2 inhibitors
Keuter et al., J Infect Dis 1995 (Typhoid Fever) : The 14-kDa group II extracellular phospholipase A2 (PLA2) is induced by interleukin-1 and tumor necrosis factor and may mediate some of the effects of these cytokines
Adamson et al., J Biochem Toxicol 1994 : Recombinant murine TNF alpha ( 0.1 microgram/mL ) caused a dose dependent increase in PLA2 activity in cultured mouse hepatocytes ... Putative PLA2 inhibitors, chlorpromazine (CPZ) and 4-bromophenacyl bromide ( BPB ), both prevented the TNF alpha induced increase in PLA2 activity ... Taken together, these results demonstrate that TNF alpha activates PLA2 , which occurs prior to other deleterious events in hepatocytes, and that inhibition of PLA2 activity reduces cell injury by TNF alpha ... Additionally, protein synthesis inhibition potentiates TNF alpha induction of PLA2 and toxicity, suggesting that there is a protein-synthesis dependent protective mechanism in hepatocytes which ameliorates the effects induced by PLA2
Wada et al., J Cell Physiol 1994 (Leukemia, T-Cell) : Phospholipase A2 activation by TNF-alpha has been shown to be important in the transduction of signals leading to cell death
Pfeilschifter et al., Eur J Clin Pharmacol 1993 : Three important classes of compounds that potently antagonise the stimulatory effect of IL-1, TNF alpha and cAMP on Group II PLA2 expression in mesangial cells have been identified, namely, glucocorticoids, transforming growth factors ( TGF ) type-beta and platelet derived growth factor ( PDGF )
Georgakopoulos et al., Biochem Biophys Res Commun 1995 : Phospholipase A2 is activated by tumor necrosis factor-alpha in primary hepatocytes stimulated by a deleted form of hepatocyte growth factor ... TNF alpha activated PLA2 in hepatocytes and it is believed that the subsequent production of PGE2 plays a role in the `` priming '' process in these cells and at the same time amplifies the proliferating signals induced by hepatocyte-specific growth factors
Wu et al., Biochim Biophys Acta 1996 : In vitro activity assay revealed that TNF-alpha increased the dithiothreitol ( DTT ) -resistant PLA2 activity which was blocked by the cPLA2 inhibitor AACOCF3
Vadas et al., Eur J Biochem 1996 : PLA2 expression in TBSMC cultures was markedly increased by tumour-necrosis factor (TNF) alpha ( 130-fold ) and interleukin-1beta (IL-1beta) ( 7.4-fold ) ... Northern blot analysis showed that TNF alpha and IL-1beta increased both PLA2 and inducible cyclooxygenase ( Cox-2 ) mRNA transcription
Endo et al., Res Commun Mol Pathol Pharmacol 1995 (Sepsis) : The results suggest that TNF-alpha and IL-6 stimulate the production of type II PLA2 in the plasma of patients with sepsis
Yan et al., Sheng Li Xue Bao 1995 : Those results indicated that PLA2 activation was involved in the TNF stimulated enhancement of neutrophil chemotaxis and adhesion
Bastian et al., Arch Dermatol Res 1996 : In this study we investigated the effects of TNF alpha and IL-1 alpha on PLA2 activity in cultured murine keratinocytes
Jayadev et al., J Biol Chem 1997 : Phospholipase A2 is necessary for tumor necrosis factor alpha induced ceramide generation in L929 cells
Chisari et al., Endocrinology 1998 : The stimulatory effect of SV and PLA2 on in vivo TNF alpha release was confirmed by in vitro experiments on peripheral mononuclear cells ; in fact, both PLA2 ( 0.001-1 microg/ml ) and SV ( 0.1-10 microg/ml ), as well as concavalin A ( 1-100 microg/ml ), were able to stimulate TNF alpha output in the incubation medium