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ANXA6 — IFNG

Text-mined interactions from Literome

Huang et al., Infect Immun 1999 : In the absence of IL-10, B. abortus LPS induced strong IFN-gamma responses, but IL-12 p70 levels were still undetectable from BALB/c spleen cells
Campbell et al., Eur J Immunol 2000 : IFN-gamma priming augmented Gal-lectin induced IL-12 mRNA expression independent of TNF-alpha and IL-1beta, and was required for IL-12 p70 protein production from macrophages and human peripheral blood mononuclear cells
Lienenlüke et al., Eur J Immunol 2000 : Despite enhancing expression of the other gene products, cytokines such as interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha, alone or in combination, failed to induce IL-12 p40 expression, whereas IFN-gamma markedly augmented CD154 induced IL-12 p40 and p70 release
Feili-Hariri et al., Clin Immunol 2001 : NOD GM + IL-4 DC produced lower amounts of IL-12 p70 following CD40 ligation or LPS stimulation in the presence of IFN-gamma than DC from other strains, although similar levels of IL-6 and NO were produced by all strains
Haskó et al., Immunology 2001 : Sulphasalazine inhibited the LPS/IFN-gamma induced production of both interleukin-12 (IL-12) p40 and p70
Petro et al., Int Immunopharmacol 2002 : Both p70 and p40 are produced by macrophages in response to lipopolysaccharide (LPS), IFN-gamma and/or CD40 ligation
Langrish et al., Clin Exp Immunol 2002 : Cord DCs were also unable to produce IL-12p70 , failed to down-regulate expression of the chemokine receptor CCR5 and induced lower levels of IFN-gamma production from allogeneic naive CD4+ T cells than their adult counterparts
Amrani et al., Am J Physiol Lung Cell Mol Physiol 2003 : Interestingly, IFN-gamma had no effect on mitogen induced activation of three major mitogenic signaling pathways, phosphatidylinositol 3-kinase, p70 ( S6k ), or mitogen activated protein kinases
Jefford et al., Blood 2003 (Melanoma) : They responded vigorously to CD40L or E coli, expressing cytokines known to regulate interferon-gamma (IFN-gamma) in T cells ( IL-12p70 , IL-18, and IL-23 ), but required prostaglandin E2 ( PGE2 ) during stimulation to migrate to chemokines
Khader et al., J Immunol 2005 (Genetic Predisposition to Disease...) : IL-12p70 induced IFN-gamma is required to control Mycobacterium tuberculosis growth ; however, in the absence of IL-12p70, an IL-12p40 dependent pathway mediates induction of IFN-gamma and initial bacteriostatic activity
Oishi et al., Cytokine 2006 : The rhG-CSF induced a pre-PHx downregulation of the IL-12p70 protein levels, while also promoting the post-PHx reduction of the protein levels of IL-12p70 and IFN-gamma
Gorski et al., Int Immunol 2006 : IL-18 and IL-12p70 were primarily required for induction of IFN-gamma by both synthetic and natural TLR-8 ligands, while type I IFN was required for induction of CD69 on NK cells by the TLR-7 agonist 3M-001
Bekeredjian-Ding et al., J Immunol 2006 : In the presence of T cell derived IL-4, but not IFN-gamma , stimulation with TLR7/8 ligands was sufficient to stimulate IL-12p70 production
Guerrero et al., Mol Immunol 2007 : Restimulation of spleen cells from primed mice with the Cry1Aa induced the production of significant levels of IL-12p70 whereas with Cry1Aa8, IFN-gamma production was stimulated
Meyers et al., Cytokine 2006 (Lupus Erythematosus, Systemic...) : Data indicate that CpG-A induced type I IFN inhibit IL-12p70 dependent PBMC IFN-gamma secretion by enhancing IL-10
Barkhuizen et al., J Infect Dis 2007 (Disease Models, Animal...) : Interleukin-12p70 dependent interferon- gamma production is crucial for resistance in African trypanosomiasis ... Although there were similar plasma levels of immunoglobulin ( Ig ) M and IgG2a in IL-12-deficient mice and wild-type mice, interferon (IFN)- gamma production, especially during early infection, was severely impaired in all IL-12p70 ( -/- ) mouse strains, demonstrating an IL-12p70 dependent mechanism for IFN- gamma production ... Because IFN- gamma receptor-deficient mice ( IFN- gamma R ( -/- ) ) were also highly susceptible to both Trypanosoma species, IL-12p70 dependent IFN- gamma production seems to be the important mechanism involved in resistance against both pathogens
Lee et al., Immunology 2008 : We found that de novo expression or overexpression of OX40L, 4-1BBL and IL-12p70 on activated B cells synergistically enhanced proliferation as well as IL-2 and interferon-gamma production by CD8+ T cells
Lamhamedi-Cherradi et al., J Immunol 2008 (Respiratory Hypersensitivity) : Exogenous IL-12p70 added to cocultures of DCs and T cells resulted in reduced IL-4 and increased IFN-gamma expression when DCs were activated with AP
Ni et al., J Invest Dermatol 2008 (Sezary Syndrome...) : We found that IFN-gamma was required for IL-12p70 production by monocyte derived DCs from SzS
Qi et al., Sci China C Life Sci 2000 : Taken together, the data suggest : ( i ) IFN-gamma/LPS could strongly induce the expression of IL-12 p40 and p35 mRNA ; both the expression levels were equal ; this phenomenon coincided with the high-level secretion of IL-12 p70 induced by IFN-gamma/LPS ; ( ii ) NF-kappaB signal pathway is essential for IFN-gamma/LPS to induce IL-12 mRNA expression ; ( iii ) by blocking the degradation of IkappaB, the PSI suppresses the IL-12 p40/p35 mRNA expression induced by LPS and IFN-gamma/LPS ; ( iv ) NF-kappaB signal may not be involved in the mechanism by which IFN-gamma enhanced the expression of the LPS induced IL-12 p40/p35 mRNA
Cooper et al., Immunol Rev 2008 (Tuberculosis) : We also show that IL-12p70 is required for the optimal interferon-gamma (IFN-gamma) T-cell response, which is required for control of Mtb growth
Richter et al., J Immunol 2009 : Finally, proving the in vivo relevance CpG adjuvant guided OVA immunization resulted in a strong augmentation of IL-12p70 dependent Th1 IFN-gamma response only in Ncf1-deficient mice
Vesosky et al., Infect Immun 2009 (Tuberculosis) : In addition, M. tuberculosis induced IFN-gamma production by CD8 T cells isolated from naïve old mice was major histocompatibility complex class I independent but was dependent on interleukin-12p70 , confirming an innate role of CD8 T cells during M. tuberculosis infection
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma , GM-CSF, TNF-alpha, and surface CD40L
Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010 : The aim of this study was to compare the effects of TNF-alpha, IL-1beta and IFN-gamma on the activation of protein kinase B (PKB), p70 ( S6k ), mitogen activated protein kinase ( MAPK ) and p90 ( rsk ), and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes
Grzelkowska-Kowalczyk et al., Cell Biol Int 2010 : The purpose of the present study was to examine the potential effect of IFN-gamma ( interferon-gamma ) on the cellular content and phosphorylation of PKB ( protein kinase B ), p70S6k ( p70 S6 kinase ) and MAPK ( mitogen activated protein kinase ), and on the ability of insulin to stimulate the glucose uptake and protein synthesis in mouse C2C12 myotubes
Snijders et al., J Immunol 1996 : We found that in LPS stimulated whole blood and purified monocytes, p70 and p40 production are enhanced by IFN-gamma and inhibited by IL-10 and IL-4
Ertel et al., Blood 1997 (Endotoxemia) : IFN-gamma dose-dependently ( P < .05 ) increased the release of IL-12 p40 and p70 into LPS stimulated whole blood from healthy humans without effect in whole blood from critically ill patients ... RhIL-12 p70 enhanced ( P < .05 ) the secretion of IFN-gamma in controls, while it was ineffective in LPS stimulated whole blood from critically ill patients
Suzumura et al., Brain Res 1998 : Microglia, but not astrocytes, produced IL-12 p70 in response to lipopolysaccharide and interferon-gamma
Isler et al., Am J Respir Cell Mol Biol 1999 : Although IFN-gamma markedly decreased LPS induced IL-10 production in AM, neutralizing IL-10 further enhanced the level of LPS and IFN-gamma induced IL-12 p70 in AM