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AHR — IL6

Text-mined interactions from Literome

Lawrence et al., Blood 2008 (Inflammation) : Functional AhR is responsible for the biologic activity of VAF347 because ( 1 ) other AhR agonists display an identical activity profile in vitro, ( 2 ) gene silencing of wild-type AhR expression or forced overexpression of a trans-dominant negative AhR ablates VAF347 activity to inhibit cytokine induced IL-6 expression in a human monocytic cell line, and ( 3 ) AhR-deficient mice are resistant to the compound 's ability to block allergic lung inflammation in vivo
Hollingshead et al., Cancer Res 2008 (Inflammation) : The studies presented herein show that, in MCF-7 breast and ECC-1 endocervical cancer cells, the stimulation of aryl hydrocarbon receptor (AHR) activity, in combination with IL-1beta or phorbol 12-myristate 13-acetate ( PMA ) treatment, results in a marked synergistic induction of IL-6 levels over what is seen without AHR activation ... Additionally, small interfering RNA studies reveal that AHR and RELA are necessary for synergistic induction of IL-6
DiNatale et al., Toxicological sciences : an official journal of the Society of Toxicology 2010 (Breast Neoplasms) : Activation of the aryl hydrocarbon receptor (AHR) with exogenous ligands coupled with inflammatory signals can lead to synergistic induction of IL6 expression in tumor cells
DiNatale et al., J Biol Chem 2010 (Inflammation) : Such data implicate the AHR in tumor expansion, although the mechanistic basis for the AHR dependent synergistic induction of IL6 has not been determined