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IL10 — PTX4
Text-mined interactions from Literome
Fujimoto et al., Intern Med 1999
(Paraparesis, Tropical Spastic) :
PTX treatment
induced incremental increases in the levels of IL-4 and
IL-10 in both sera and CSF of 6 HAM patients
Marcinkiewicz et al., Immunopharmacology 2000
:
PTX also
affects the production of other cytokines such as IL-1, IL-6,
IL-10 , IL-12, and IFN-gamma ... However, at higher concentrations,
PTX inhibited the production of TNF-alpha,
IL-10 , and IL-12 p35, but surprisingly, PTX enhanced the production of IL-12 p40
Ji et al., Ann Clin Lab Sci 2004
(Disease Models, Animal...) :
At all dosages,
PTX reduced the activation of NF-kappaB and the production of TNF-alpha and IL-6, but
enhanced the release of
IL-10 ... In conclusion,
PTX suppressed the production of proinflammatory cytokines such as TNF-alpha and IL-6 in rat intestine, and
enhanced the endotoxin induced production of
IL-10
Schneider et al., Infect Immun 2007
:
Stimulation of T cells with holotoxin (
PTx ) or the B subunit alone ( PTxB ) rapidly
induces signaling events resulting in inositol phosphate accumulation, Ca ( 2+ ) mobilization,
interleukin-2 (IL-2) production, and mitogenic cell growth
van Furth et al., Clin Diagn Lab Immunol 1995
:
The release of
IL-10 was significantly
reduced by
PTX at 24 h and by caffeine at 48 h, but DXM increased the release of this cytokine
Navarro et al., AIDS 1996
:
Moreover,
PTX reduced TNF-alpha, IFN-gamma and
IL-10 production and NF-kappa B activation
Dong et al., J Clin Immunol 1997
:
PTX at a 3.5 x 10 ( -5 ) M concentration significantly
inhibited T cell proliferation and the production of tumor necrosis factor-alpha,
interleukin-2 , and interleukin-4
D'Hellencourt et al., Int J Immunopharmacol 1996
:
We investigated
PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta and
IL-10 ... We also noted that the
effects of
PTX on IL-6, IL-8 and
IL-10 production were different in WB and in PBMC culture
Schratzberger et al., Immunopharmacology 1999
:
In the present study, we investigated the
effects of the anti-inflammatory drug
pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF),
interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )