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CDC27 — PLK1

Pathways - manually collected, often from reviews:

• Reactome Reaction: CDC27 → PLK1 (indirect_complex)
• Reactome Reaction: CDC27 → PLK1 (reaction) Golan et al., J Biol Chem 2002, Kraft et al., EMBO J 2003

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 15 proteins (association, pull down) Gong et al., J Biol Chem 2009

Text-mined interactions from Literome

Liu et al., Proc Natl Acad Sci U S A 2002 : Plks have been reported to mediate multiple mitotic processes, including bipolar spindle formation, activation of Cdc25C, actin ring formation, centrosome maturation, and activation of the anaphase promoting complex
van Vugt et al., J Biol Chem 2004 : These data indicate that activation of the anaphase promoting complex or cyclosome ( APC/C ) -Cdc20 complex that is under control of the spindle assembly checkpoint does not require Plk1 activity ... These data indicate that activation of the anaphase promoting complex or cyclosome ( APC/C ) -Cdc20 complex that is under control of the spindle assembly checkpoint does not require Plk1 activity
Hansen et al., Mol Biol Cell 2004 : Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP dependent destruction of the APC Inhibitor Emi1
Kotani et al., Mol Cell 1998 : PKA and MPF activated polo-like kinase regulate anaphase promoting complex activity and mitosis progression