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AGTR1 — PHKA2

Text-mined interactions from Literome

Matsubara et al., Biochem Biophys Res Commun 2001 : AT2 did not affect AT1 mediated Pyk2 phosphorylation, but attenuated c-Jun mRNA accumulation by 32 %
Shah et al., Mol Pharmacol 2002 : Agonist activation of endogenous angiotensin II (Ang II) AT(1) receptors expressed in hepatic C9 cells markedly stimulated inositol phosphate production, phosphorylation of the proline-rich tyrosine kinase PyK-2 , and ERK activation
Portela et al., J Biol Chem 2002 : Pyk1 activity was measured at different phosphoenolpyruvate concentrations in the absence or in the presence of the activator fructose 1,6-bisphosphate at 1.5 mm. Preliminary kinetic results derived from the comparison of Pyk1 obtained from extracts with the highest versus those from the lowest protein kinase A activity indicate that the enzyme is more active upon phosphorylation conditions ; in the absence of the activator it shows a shift in the titration curve for phosphoenolpyruvate to the left and an increase in the Hill coefficient, whereas in the presence of fructose 1,6-bisphosphate it shows an n ( H ) value of 1.4, as compared with an n ( H ) of 2 for the Pyk1 obtained from extracts with almost null protein kinase A activity
Sabri et al., Circ Res 1998 : PYK2 phosphorylation was inhibited by AT1 receptor blockade and was attenuated by downregulation of PKC or the chelation of [ Ca2+ ] i. Treatment with either phorbol ester or Ca2+ ionophore also increased PYK2 phosphorylation, suggesting that PKC activation and/or increased [ Ca2+ ] i are both necessary and sufficient to activate PYK2