Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
HIF1A
→
IGF1R
(increases, HIF1A Activity)
Evidence: Several growth factors, most notably insulin-like growth factor-2 (IGF2) and transforming growth factor-a (TGF-a), are also HIF-1 target genes. Binding of these factors to their cognate receptors the insulin-like growth factor 1 receptor (IGF1R) and epidermal growth-factor receptor (EGFR), respectively activates signal-transduction pathways that lead both to HIF-1a expression (as described above) and to cell proliferation survival. HIF-1 therefore contributes to autocrine-signalling pathways tha...