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PROX1 — TP53
Text-mined interactions from Literome
Foskolou et al., Oncogene 2013
(Neuroblastoma) :
Most importantly,
Prox1 was
sufficient to decrease Cdc25A and induce p27-Kip1, but not p21-Cip1 or
p53
Liu et al., Curr Mol Med 2012
:
The
tumor suppressor p53 regulates c-Maf and
Prox-1 to control lens differentiation ... Here we present evidence that
p53 directly
regulates c-Maf and
Prox1 , two important transcription factors controlling differentiation in the ocular lens
Chang et al., Cancer Biol Ther 2013
(Carcinoma, Hepatocellular...) :
The homeobox transcription factor
Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing
p53 dependent senescence-like phenotype
Ji et al., Curr Mol Med 2013
:
Regarding the mechanism, we reveal that
p53 directly
regulates c-Maf and
Prox1 , two important transcription factors to control cell differentiation in the ocular lens