Gene interactions and pathways from curated databases and text-mining

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PROX1 — TP53

Text-mined interactions from Literome

Foskolou et al., Oncogene 2013 (Neuroblastoma) : Most importantly, Prox1 was sufficient to decrease Cdc25A and induce p27-Kip1, but not p21-Cip1 or p53
Liu et al., Curr Mol Med 2012 : The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation ... Here we present evidence that p53 directly regulates c-Maf and Prox1 , two important transcription factors controlling differentiation in the ocular lens
Chang et al., Cancer Biol Ther 2013 (Carcinoma, Hepatocellular...) : The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53 dependent senescence-like phenotype
Ji et al., Curr Mol Med 2013 : Regarding the mechanism, we reveal that p53 directly regulates c-Maf and Prox1 , two important transcription factors to control cell differentiation in the ocular lens