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DYRK1A — NOTCH4

Text-mined interactions from Literome

Fernandez-Martinez et al., J Cell Sci 2009 (Down Syndrome) : DYRK1A attenuates Notch signalling in neural cells both in culture and in vivo, constituting a novel mechanism capable of modulating different developmental processes that can also contribute to the alterations observed during brain development in animal models of Down syndrome
Hämmerle et al., Development 2011 : Furthermore, we found that MNB/DYRK1A suppressed NOTCH signaling, counteracted the pro-proliferative action of the NOTCH intracellular domain ( NICD ), stimulated Delta1 expression and was required for the neuronal differentiation induced by the decrease in NOTCH signaling