◀ Back to VEGFA
PIK3R1 — VEGFA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Dong et al., Cancer Res 2001
(Carcinoma, Squamous Cell...) :
Hepatocyte growth factor/scatter factor induced activation of MEK and
PI3K signal pathways
contributes to expression of proangiogenic cytokines interleukin-8 and
vascular endothelial growth factor in head and neck squamous cell carcinoma ... Inhibitors of MEK ( U0126 ) and
PI3K ( LY294002 ) blocked p42/p44 ( erk ) and Akt, respectively, and partially
blocked HGF induced production of IL-8 and
VEGF , whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A
Huang et al., J Biol Chem 2002
:
Phosphatidylinositol 3-kinase is
activated by
vascular endothelial growth factor ( VEGF ), and many of the angiogenic cellular responses of VEGF are regulated by the lipid products of phosphatidylinositol 3-kinase
Woods et al., Neuro Oncol 2002
(Astrocytoma...) :
Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially
regulate expression of
vascular endothelial growth factor in human malignant astrocytoma cells
Burroughs et al., Mol Cancer Res 2003
(MAP Kinase Signaling System) :
Mutation of the hypoxia response element ( HRE ), which mediates hypoxic stimulation of VEGF transcription, did not inhibit the effect of IGF-I on the VEGF promoter, despite the fact that this mutation inhibited
PI3-K stimulated
VEGF promoter activity in prostate cancer cells ... These data indicate that
PI3-K signaling does not
increase VEGF transcription through transactivation by HIF-1 at the HRE in normal PrEC
Li et al., Brain Res Mol Brain Res 2003
(Amyotrophic Lateral Sclerosis...) :
VEGF activated both
PI3-K and MAPK activities in mouse NSC34 motor neuron-like cells
Zhang et al., J Biol Chem 2003
:
Phosphorylation of VEGFR2 at Tyr-801 and Tyr-1175, the critical sites for
VEGF induced
PI3K-Akt signaling, was not involved in TNF mediated Akt activation ... Taken together, our data demonstrated that TNF induces transactivation between Etk and VEGFR2, and Etk directly activates
PI3K-Akt angiogenic signaling independent of
VEGF induced VEGFR2-PI3K-Akt signaling pathway
Giuliani et al., Leukemia 2004
(Multiple Myeloma...) :
Moreover, we also found that the
PI3K kinase inhibitors, but not p38 MAPK inhibitors,
reduced VEGF secretion by myeloma cells and increase the inhibitory effect of MEK1 inhibitors
Huang et al., World J Gastroenterol 2004
(Carcinoma, Hepatocellular...) :
Effects of
PI3K and p42/p44 MAPK on overexpression of
vascular endothelial growth factor in hepatocellular carcinoma
Flaxenburg et al., J Immunol 2004
:
Also, wortmanin and a dominant-inhibitory mutant of
PI3K inhibited CD40 induced overexpression of
VEGF
Hellwig-Bürgel et al., Cell Physiol Biochem 2005
:
Thus,
PI3K signaling is
required for HIF-1alpha accumulation and
VEGF synthesis, whereas MAPKK-1 signaling is required for VEGF synthesis only
Trisciuoglio et al., Mol Biol Cell 2005
(MAP Kinase Signaling System...) :
Involvement of
PI3K and MAPK signaling in bcl-2 induced
vascular endothelial growth factor expression in melanoma cells
Lee et al., Mol Pharmacol 2006
(Asthma...) :
This study aimed to determine the
effect of
PI3K inhibitors and PTEN on
VEGF expression in allergen induced airway inflammation
Wood et al., J Cell Biol 2006
:
In contrast, using both laser ablation and a novel wounding assay that allows localized treatment with inhibitory drugs, we show that
PI3K is essential for hemocyte chemotaxis toward wounds and that Pvf signals and
PDGF/VEGF receptor expression are not
required for this rapid chemotactic response
Slomiany et al., J Pharmacol Exp Ther 2006
(Anoxia) :
IGF-1 stimulated VEGF promoter activity was phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR ( mammalian target of rapamycin ) -dependent, whereas
VEGF secretion was only partially
reduced by inhibition of
PI3K/Akt/mTOR and HIF-1 activities
Tang et al., Mol Cancer Res 2006
(Breast Neoplasms...) :
Furthermore, the
PI3K-specific inhibitor LY294002
inhibited VEGF production by EMMPRIN overexpressing cells in a dose- and time dependent manner
Li et al., Int J Mol Med 2006
:
Further, we found that
PI3K inhibitors, LY294002 and Wortmannin,
inhibited HIF-1alpha and
VEGF expression induced by UV radiation
Kang et al., Oncogene 2008
(Neovascularization, Pathologic...) :
Our results show that N-myc plays an important role in the
PI3K mediated
VEGF regulation in NB cells
Banerjee et al., Biochemistry 2008
(Breast Neoplasms) :
Neutralization of VEGF action by its antibody or inhibition of
VEGF induced
PI3K/Akt kinase
activation by wortmannin, a PI3K/Akt specific inhibitor, results in inhibition of VEGF induced hAOSMC migration
Lu et al., Microvasc Res 2009
(Lung Neoplasms...) :
Furthermore, lenalidomide inhibited
VEGF induced
PI3K-Akt pathway signaling, which is known to regulate adherens junction formation
Guo et al., Stroke 2009
:
In contrast, neither inhibition of GSK-3beta nor inhibition of
PI3-K had any detectable effects on
VEGF levels in astrocytes
García-Maceira et al., Oncogene 2009
(Carcinoma, Hepatocellular) :
Moreover, silibinin reduced hypoxia induced
vascular endothelial growth factor ( VEGF ) release by HeLa and Hep3B cells, and this effect was
potentiated by the
PI3K/Akt inhibitor LY294002
Yang et al., Invest Ophthalmol Vis Sci 2009
(Anoxia...) :
Role of
PI3K/Akt and MEK/ERK in mediating hypoxia induced expression of HIF-1alpha and
VEGF in laser induced rat choroidal neovascularization ... A well established rat model of CNV and cultured human retinal pigment epithelium ( hRPE ) was used to investigate the
role of
PI3K/Akt and MEK/ERK pathways in regulating HIF-1alpha and
VEGF expression in CNV in rat and hRPE under hypoxia by immunohistochemistry, Western blot analysis, real-time PCR, and ELISA
Lu et al., Am J Respir Cell Mol Biol 2010
(Neovascularization, Pathologic...) :
Activation of
PI3K/Akt by bleomycin also
led to transcriptional activation and protein expression of hypoxia-inducible factor-1alpha ( HIF-1alpha ) and
vascular endothelial growth factor , which contributed to the fibroproliferative and collagen inducing effects of bleomycin
Jiang et al., Adv Cancer Res 2009
(Neoplasms...) :
PI3K signaling
regulates tumor growth and angiogenesis by activating AKT and other targets, and by inducing HIF-1 and
VEGF expression
Dai et al., Oncogene 2009
:
In turn, OPN induced
VEGF activates
PI3K/AKT and the ERK1/2 pathway as a positive feedback signal
Elayappan et al., Angiogenesis 2009
:
Of interest, PEDF effectively abrogated
VEGF mediated phosphorylation of
PI3K/Akt
Westra et al., Ann N Y Acad Sci 2009
(Arthritis, Rheumatoid) :
Protein and mRNA expression of HIF-1alpha and the
effects of inhibitors of the CaMKII-,
PI3K- , and ERK pathway on
VEGF and IL-6 production were analyzed
Chetty et al., Int J Cancer 2010
(Lung Neoplasms) :
We also show that MMP-2 suppression disrupted
PI3K dependent
VEGF expression ; ectopic expression of myr-AKT restored VEGF inhibition
Westra et al., BMC musculoskeletal disorders 2010
(Arthritis...) :
THP-1 and SF macrophages produced high levels of VEGF, IL-8, and MMP-9, and
VEGF protein production was significantly
inhibited by
PI3K-inhibitor , and by both CaMKII inhibitors
Lee et al., FEBS Lett 2010
:
We demonstrate that reduction in Ca ( 2+ ) by chelating compound BAPTA-AM or by IP ( 3 ) -endoplasmic reticulum blocker 2-APB selectively inhibited
VEGF induced activation of
c-Src-PI3K-Akt but not ERK1/2 in human coronary artery endothelial cells ( HCAEC ) ... We also show that the selective inhibitory effects of NADPH oxidase knockdown on
VEGF mediated
activation of
c-Src-PI3K-Akt signaling and cell proliferation in HCAEC can be reversed by increase in intracellular Ca ( 2+ )
Jang et al., BMC cancer 2010
(Breast Neoplasms...) :
Inhibition of
PI3K/Akt signaling by ANT2 shRNA
caused down-regulation of membrane-type 1 matrix metalloproteinase ( MT1-MMP ) and
vascular endothelial growth factor ( VEGF ) expression, decreased matrix metalloproteinase 2 (MMP2) and MMP9 activity, and suppressed migration and invasion of breast cancer cells
Luangdilok et al., Eur J Cancer 2011
(Carcinoma, Squamous Cell...) :
In both cell lines stimulated with endogenous or exogenous ligand, inhibition of MEK1/2 ( with U0126 or PD98059 ) or
PI3K ( with PI-103 or LY294002 )
resulted in a marked reduction of EGFR induced
VEGF-A expression, whereas exogenous EGF induced VEGF-C upregulation was blocked by inhibitors of MEK but not PI3K
Yu et al., Cancer Chemother Pharmacol 2011
(Carcinoma, Non-Small-Cell Lung...) :
The
PI3 K or ERK inhibitors also
attenuated expression of
VEGF and MMP-9
Yin et al., J Mol Med (Berl) 2011
(Disease Models, Animal...) :
PI3K inhibitor LY294002 significantly
attenuated Rg1 enhanced
VEGF expression and capillary density
Li et al., Zhongguo Dang Dai Er Ke Za Zhi 2011
(Neuroblastoma) :
The synthesis and secretion of
VEGF can be
inhibited by blocking TrkB-BDNF signal pathway with K252a or blocking the TrkB-BDNF downstream signal pathway
PI3K/Akt with LY294002
Lee et al., Mol Cells 2011
(Breast Neoplasms) :
Moreover, the higher production of
vascular endothelial growth factor ( VEGF ) in TAMR-MCF-7 cells was significantly
diminished by suppression of
PI3K or p38 kinase
Ghosh et al., J Biol Chem 2012
(MAP Kinase Signaling System...) :
Therefore, based on these observations, it is hypothesized that the
activation of
PI3K/AKT and p38 MAPK by
VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells
Ruan et al., EMBO J 2012
:
Axl is essential for
VEGF-A dependent activation of
PI3K/Akt ... These results elucidate the mechanism by which
VEGF-A activates
PI3K/Akt , and identify previously unappreciated potential therapeutic targets of VEGF-A-driven processes
Xu et al., PloS one 2012
(Liver Neoplasms) :
Addition of recombinant human
VEGF attenuated the inhibitory effects of PP on
PI3K/AKT pathway and the cancer phenotypes
Chen et al., Mol Nutr Food Res 2012
:
Moreover, lycopene attenuated
VEGF receptor-2 (VEGFR2) mediated phosphorylation of extracellular signal regulated kinase ( ERK ), p38, and Akt as well as protein expression of
PI3K
Poettler et al., Thromb Haemost 2012
:
Thus, VEGF165,
VEGF-E , FGF-2, EGF as well as HGF
induced a
PI3k dependent activation of pro-uPA when bound to uPAR, which led to an increase in cell surface fibrinolytic activity
Piccolo et al., J Mol Med (Berl) 2013
(Breast Neoplasms...) :
Production of
VEGF , that was restored by exposure of silenced cells to recombinant LGALS3BP,
required an intact
PI3k/Akt signaling
Genini et al., PloS one 2012
(Carcinoma, Non-Small-Cell Lung...) :
Induction of
VEGF was
due to both binding of PPARß/d to the VEGF promoter and
PI3K activation through a non-genomic mechanism
Jang et al., Br J Pharmacol 2013
(Wounds, Penetrating) :
Both an AMPK inhibitor ( compound C ) anda HO-1 activity inhibitor ( SnPPIX ) but not inhibitors of MAPKs,
PI3K and PKC
reduced the production of
VEGF by CKD712
Bhattacharya et al., J Neurooncol 2013
(Brain Neoplasms...) :
T11TS therapy in rodent glioma model significantly downregulated expression of
VEGF along with its receptor VEGFR-2 and
inhibited the expression of pro-survival
PI3K/Akt/eNOS proteins in glioma associated brain endothelial cells
Lo et al., International journal of molecular sciences 2013
:
In parallel,
VEGF induced JNK,
PI3K and Akt activation
Sun et al., PloS one 2013
:
Our results show that baicalein induced Epo and
VEGF expression in a HIF1a- and
PI3K/Akt dependent manner in neurons