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RAF1 — VEGFA

Text-mined interactions from Literome

D'Angelo et al., Mol Endocrinol 1999 : 16K hPRL treatment blocked VEGF induced Raf-1 activation as well as its translocation to the plasma membrane
Sasaki et al., Nat Cell Biol 2003 (MAP Kinase Signaling System) : Here we show that mammalian Sprouty4 suppresses vascular epithelial growth factor (VEGF) induced , Ras independent activation of Raf1 but does not affect epidermal growth factor (EGF) induced, Ras dependent activation of Raf1
Alavi et al., Science 2003 (Neovascularization, Pathologic) : In contrast, VEGF activated Raf-1 via Src kinase, leading to phosphorylation of tyrosines 340 and 341 and MEK1 dependent protection from extrinsic mediated apoptosis
Hood et al., J Cell Biol 2003 : Inhibition of FAK or alphavbeta5 disrupted VEGF mediated Ras and c-Raf activity on the chick chorioallantoic membrane, whereas blockade of FAK or integrin alphavbeta3 had no effect on bFGF mediated Ras activity, but did suppress c-Raf activation
Mariappan et al., J Biol Chem 2005 : VEGF also stimulated phosphorylation of Pyk-2 ; VEGF induced phosphorylation of Pyk2, c-Src and Raf-1 could be abolished by BAPTA/AM, demonstrating requirement for induction of intracellular calcium currents
Izbicka et al., Anticancer Res 2005 (Breast Neoplasms...) : R115777 +/- paclitaxel inhibited HDJ-2 farnesylation, up-regulated RhoB, transiently lowered ( P ) ERK/ERK and ( P ) Akt/Akt, reduced Raf-1 and MEK and inhibited secretion of VEGF and MMP-1
Yang et al., Oncogene 2013 (Melanoma...) : In conclusion, our findings provide evidence that GAB2 is a novel regulator of tumor angiogenesis in NRAS-driven melanoma through regulation of HIF-1a and VEGF expressions mediated by RAS-RAF-MEK-ERK signaling
Gong et al., Yao Xue Xue Bao 2013 (MAP Kinase Signaling System) : Further results showed that moscatilin inhibited VEGF induced activation of c-Raf and MEK1/2, which are both upstream signals of ERK1/2
Hood et al., J Biol Chem 1998 : Protein kinase G mediates vascular endothelial growth factor induced Raf-1 activation and proliferation in human endothelial cells ... VEGF induced proliferation and Raf-1 kinase activity were also inhibited by Rp-8-pCPT-cGMPs and KT5823, inhibitors of the regulatory and catalytic subunits of cGMP dependent protein kinase ( PKG ), respectively ... We conclude that VEGF induces increases in both proliferation and Raf-1 kinase activity in HUVECs and these activities are dependent on NO and its downstream effector, PKG