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LPA — SPHK1

Text-mined interactions from Literome

Shida et al., Cancer Res 2008 (Breast Neoplasms...) : LPA also up-regulated SphK1 expression in other human cancer cells that endogenously express the LPA ( 1 ) receptor, such as DLD1 colon cancer cells and MDA-MB-231 breast cancer cells, but not in HT29 colon cancer cells or MDA-MB-453 breast cancer cells, which do not express the LPA ( 1 ) receptor ... LPA transactivated the epidermal growth factor receptor (EGFR) in these cells, and the EGFR inhibitor AG1478 attenuated the increased SphK1 and S1P(3) expression induced by LPA
Ramachandran et al., FEBS Lett 2010 (Stomach Neoplasms) : In MKN1 gastric cancer cells, lysophosphatidic acid (LPA) upregulates expression of sphingosine kinase 1 (SphK1) and its downregulation or inhibition suppresses LPA mediated proliferation ... Although LPA activates numerous signaling pathways downstream of its receptors, including extracellular-signal regulated kinase 1/2, p38, JNK, and Akt, and the transactivation of the epidermal growth factor receptor, pharmacological and molecular approaches demonstrated that only activation of ERK1, in addition to the CCAAT/enhancer binding protein ß transcription factor, is involved in transcriptional upregulation of SphK1 by LPA