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Kobayashi et al., J Biol Chem 2001 (MAP Kinase Signaling System...) : PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun dependent uPA expression
Dunn et al., Cancer Res 2001 (Breast Neoplasms...) : In summary, we conclude that IGF-I requires both phosphatidylinositol 3-kinase and mitogen activated protein kinase kinase dependent pathways to optimally induce uPA expression
Witowsky et al., J Biol Chem 2003 : Further, we show that growth factor induced uPA expression requires MEKK1 dependent MKK1 and JNK activity and that transfection of MEKK1 into knockout cells restores inducible uPA expression and activity
Lee et al., Clin Exp Metastasis 2003 (MAP Kinase Signaling System...) : To investigate the role of HGF/c-met signaling on metastasis in cancer cells stimulated with HGF, we examined the effects of a specific MEK1 inhibitor ( PD98059 ) and a p38 MAP kinase inhibitor ( SB203580 ) on HGF induced uPA expression in pancreatic cancer cell lines, L3.6PL and IMIM-PC2
Mahabeleshwar et al., J Biol Chem 2004 (Anoxia...) : DN Lck and inhibitors of Lck, EGF receptor, and MEK-1 suppressed H/R induced uPA secretion and cell motility ... To our knowledge, this is the first report that p56 ( lck ) in presence of H/R regulates MEK-1 dependent ERK1/2 phosphorylation and uPA secretion through tyrosine phosphorylation of EGF receptor, and it further demonstrates that all of these signaling molecules ultimately control the motility of breast cancer cells
Nicholl et al., J Vasc Surg 2005 : Activation of the mitogen activated protein kinases ( MAPK ), extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38 MAPK, Akt, MAP kinase/ERK kinase ( MEK1/2 ), MAP kinase kinase (MKK)3/6, and epidermal growth factor receptor (EGFR) in response to uPA was assayed by Western blot analysis for the phosphorylated form of each kinase
Lee et al., Exp Mol Med 2006 (Neoplasm Metastasis...) : In order to investigate roles of HGF/c-Met signaling in tumor progression and metastasis in stomach cancers, we determined effects of a specific MEK1 inhibitor ( PD098059 ) and a p38 kinase inhibitor ( SB203580 ) on HGF mediated cell proliferation and uPA expression in stomach cancer cell lines ( NUGC-3 and MKN-28 )