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EGF — PAK6
Text-mined interactions from Literome
Beeser et al., J Biol Chem 2005
:
Inhibition of
Pak kinase activity dramatically decreased phosphorylation of Mek1 at Ser ( 298 ) in
response to either PDGF or
EGF , but this inhibition did not prevent Mek1 activation by EGF, suggesting that although Pak can phosphorylate Mek1 at Ser ( 298 ), this event is not required for Mek1 activation by growth factors
Beier et al., Atherosclerosis 2008
:
In VSMC,
EGF sequentially
stimulated PAK , peaking at 5 min, and JNK, peaking at 15 min. Pretreatment of VSMC by EGF receptor specific tyrosine kinase inhibitor AG1478 and non-specific tyrosine kinase inhibitor genistein inhibited EGF induced activation of Rac1, PAK and JNK, whereas tyrosine kinase inhibitors specific for Src ( PP1 ) and specific for platelet derived growth factor ( AG1296 ) had no effect
Yang et al., Journal of biomedical research 2011
:
Interestingly,
EGF could
induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF induced ROS generation, cell migration, as well as activation of PI3K/Akt and
PAK , but not Rac1