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EGF — RAC3

Text-mined interactions from Literome

Gay et al., J Biol Chem 1999 : In the current study, we establish that these inhibitors inhibit hepatocyte growth factor/scatter factor induced A431 and Madin-Darby canine kidney cell motility and various cell motility related events, including epidermal growth factor induced ruffling of A431 cells and epidermal growth factor induced translocation of the small GTPase Rac in these cells
Marignani et al., J Cell Biol 2001 : Studies using this mutant indicate that Vav2 is not necessary for platelet derived growth factor- or epidermal growth factor dependent activation of Rac
Maddala et al., Molecular vision 2003 : Rac GTPase activation, in contrast, was significantly enhanced in response to only EGF or b-FGF
Marcoux et al., Oncogene 2003 : EGF receptor mediates adhesion dependent activation of the Rac GTPase : a role for phosphatidylinositol 3-kinase and Vav2
Zahir et al., J Cell Biol 2003 (Breast Neoplasms...) : Instead, the cytoplasmic tail of beta4 integrin is necessary for basal and epidermal growth factor induced RAC activity, and RAC mediates tumor survival
Beier et al., Atherosclerosis 2008 : However, the effect of EGF on Rac/Cdc42 activation is unknown for VSMC ... In the present report, we evaluated stimulation of Rac/Cdc42 by EGF in VSMC performing PAK-PBD binding assay
Dise et al., Am J Physiol Gastrointest Liver Physiol 2008 : Whereas EGF failed to activate Rac in colon cells from EGF receptor (EGFR) knockout mice, stable expression of wild-type EGFR restored EGF stimulated Rac activation and migration ... Pharmacological inhibition of either phosphatidylinositol 3-kinase (PI3K) or Src family kinases reduced EGF stimulated Rac activation ... Cotreatment of cells with both inhibitors completely blocked EGF stimulated Rac activation and localization to the leading edge of cells and lamellipodial extension
Everett et al., J Biol Chem 2009 : Analysis of PLC gamma 1 and PLC gamma 2 with point mutations of this residue showed that removal of the negative charge enhanced PLC activity in response to EGF stimulation or activation by Rac
Kim et al., FEBS Lett 1997 : By reporter gene analysis following transient or stable transfections with pEXV-RacN17 encoding a dominant negative mutant of Rac, EGF induced activation of c-fos SRE-luciferase gene was shown to be selectively inhibited, suggesting that Rac activity is necessary for the full activation of SRE by EGF
Malliri et al., J Cell Biol 1998 : However, EGF induced translocation of Rac to the cell membrane, which is associated with its activation, is defective in TA cells