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NANOG — SIRT1
Text-mined interactions from Literome
Han et al., Cell stem cell 2008
:
SIRT1 regulates apoptosis and
Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization ... Endogenous ROS triggered apoptosis of wild-type mES through mitochondrial translocation of p53 and BAX but inhibited Nanog expression of SIRT1 ( -/- ) mES, indicating that
SIRT1 makes mES cells sensitive to ROS and
inhibits p53 mediated suppression of
Nanog expression
Calvanese et al., Proc Natl Acad Sci U S A 2010
:
The longevity promoting NAD+ dependent class III histone deacetylase
Sirtuin 1 (SIRT1) is
involved in stem cell function by controlling cell fate decision and/or by regulating the p53 dependent expression of
NANOG